For almost two decades, breast cancer clinical genetics has operated in an environment
where a heritable cause of breast cancer susceptibility is identified in the vast minority of …

PALB2 has taken its place with bona fide breast cancer susceptibility genes. It is now well
established that women who carry loss-of-function mutations in the PALB2 gene are at …

It has been shown that the loss of function of the BRCA1, BRCA2, and PALB2 genes due to
a number of hereditary mutations or chromosomal aberrations can affect the effectiveness of …

Abstract Background PALB2 (Partner and Localizer of BRCA2) is recently recognized as a
breast cancer predisposition gene. Germline loss-of-function mutations in PALB2 lead to …

Inherited mutations in PALB2 are known to be associated with increased breast cancer risk.
We aimed to investigate the prevalence and risk association of a recurrent PALB2 mutation …

Background Germline mutations in PALB2 have been identified in approximately 1% of
familial breast cancer (BC) in several populations. Nevertheless its contribution in the South …

Background PALB2 has emerged as a breast cancer susceptibility gene. Mutations in
PALB2 have been identified in almost all breast cancer populations studied to date, but the …

Purpose: Monoallelic germ-line deleterious mutations of PALB2 (partner and localizer of
BRCA2) are associated with breast cancer risk and have been found in several populations …

Background: Population-based studies of breast cancer have estimated that at least some
PALB2 mutations are associated with high breast cancer risk. For women carrying PALB2 …

Objective Approximately 20% of ovarian cancers are due to an underlying germline
pathogenic variant. While pathogenic variants in several genes have been well-established …