Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …

Adequate intake of the essential trace element and micronutrient selenium is thought to be
beneficial for maintaining human health. Selenium may modulate a broad spectrum of key …

Organoselenium compounds have found such wide utility because of their effects on an
extraordinary number of very different reactions, including many carbon-carbon bond …

The element selenium was discovered in 1818 by the Swedish chemist Berzelius and was
named after the Greek goddess of the moon, Selene. 1 In biology, selenium was long …

Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. It is a
multifunctional compound, which catalyzes several essential reactions for the protection of …

The advance in the area of synthesis and reactivity of organoselenium, as well as the
discovery that selenium was the cause of severe intoxication episodes of livestock in the …

A free radical is any species capable of independent existence that contains one or more
unpaired electrons. Free radical reactions have been implicated in the pathology of more …

Highly toxic metabolites of oxygen are generated normally by aerobic metabolism in most
cells, and this generation is often greatly increased in pathologic conditions. When this …

The selenoorganic compound ebselen, 2-phenyl-1, 2-benzisoselenazol-3 (2H)-one, exhibits
activity as an enzyme mimic. The reaction catalyzed is that of a glutationed (GSH) …

1. Ebselen (2-phenyl-1, 2-benzisoselenazol-3 (2H)-one) is a non-toxic seleno-organic drug
with antiinflammatory, antiatherosclerotic and cytoprotective properties. 2. 2. Ebselen and …