Antivirals and vaccines for Enterovirus A71

JY Lin, YA Kung, SR Shih - Journal of biomedical science, 2019 - Springer
Abstract Enterovirus A71 (EV-A71) is an important emerging virus posing a threat to children
under five years old. EV-A71 infection in infants or young children can cause hand-foot-and …

Diseases caused by enterovirus 71 infection

TC Lee, HR Guo, HJJ Su, YC Yang… - The Pediatric …, 2009 - journals.lww.com
The purpose of this review was to explore the epidemiology, pathogenesis, virology, and
management of enterovirus 71 (EV71) infection. Published literature was surveyed by …

[HTML][HTML] The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains

Y Wu, A Yeo, MC Phoon, EL Tan, CL Poh… - International Journal of …, 2010 - Elsevier
BACKGROUND: During 2008, Singapore experienced its largest ever outbreak of hand, foot
and mouth disease (HFMD), resulting in 29686 cases, including four cases of encephalitis …

[HTML][HTML] Advances in anti-EV-A71 drug development research

S Wang, Z Pang, H Fan, Y Tong - Journal of Advanced Research, 2024 - Elsevier
Abstract Background Enterovirus A71 (EV-A71) is capable of causing hand, foot and mouth
disease (HFMD), which may lead to neurological sequelae and even death. As EV-A71 is …

EV71: an emerging infectious disease vaccine target in the Far East?

J Xu, Y Qian, S Wang, JMG Serrano, W Li, Z Huang… - Vaccine, 2010 - Elsevier
Hand, foot, and mouth disease (HFMD) is a common viral illness in infants and children
caused by viruses that belong to the enterovirus genus of the picornavirus family. Although …

The virology and developments toward control of human enterovirus 71

L Yi, J Lu, H Kung, ML He - Critical reviews in microbiology, 2011 - Taylor & Francis
Enterovirus 71 (EV71), a member of the Enterovirus genus in the Picornaviridae family, was
first recognized as a dermotrophic virus that usually cause mild, self-limiting hand-foot-and …

Immunopathogenesis and virus–host interactions of enterovirus 71 in patients with hand, foot and mouth disease

JA Cox, JA Hiscox, T Solomon, MH Ooi… - Frontiers in …, 2017 - frontiersin.org
Enterovirus 71 (EV71) is a global infectious disease that affects millions of people. The virus
is the main etiological agent for hand, foot, and mouth disease with outbreaks and …

EV-A71 mechanism of entry: Receptors/co-receptors, related pathways and inhibitors

K Hu, R Onintsoa Diarimalala, C Yao, H Li, Y Wei - Viruses, 2023 - mdpi.com
Enterovirus A71, a non-enveloped single-stranded (+) RNA virus, enters host cells through
three stages: attachment, endocytosis and uncoating. In recent years, receptors/co-receptors …

Antiviral drug discovery for the treatment of enterovirus 71 infections

L Shang, M Xu, Z Yin - Antiviral research, 2013 - Elsevier
Enterovirus 71 (EV71) is a small, positive-sense, single-stranded RNA virus in the genus
Enterovirus, family Picornavirus. It causes hand, foot and mouth disease in infants and …

Identification of luteolin as enterovirus 71 and coxsackievirus A16 inhibitors through reporter viruses and cell viability-based screening

L Xu, W Su, J Jin, J Chen, X Li, X Zhang, M Sun, S Sun… - Viruses, 2014 - mdpi.com
Hand, foot and mouth disease (HFMD) is a common pediatric illness mainly caused by
infection with enterovirus 71 (EV71) and coxsackievirus A16 (CA16). The frequent HFMD …