Obesity is caused by a long-term difference between energy intake and expenditure—an
imbalance that is seemingly easily restored by increasing exercise and reducing caloric …

Obesity and obesity-associated disorders pose a major public health issue worldwide. Apart
from conventional weight loss drugs, next-generation probiotics (NGPs) seem to be very …

Succinate is a circulating metabolite, and the relationship between abnormal changes in the
physiological concentration of succinate and inflammatory diseases caused by the …

Centenarians are an excellent model to study the relationship between the gut microbiome
and longevity. To characterize the gut microbiome signatures of aging, we conducted a …

Background 2, 5-dimethylcelecoxib (DMC), a derivative of celecoxib, is an inhibitor of
microsomal prostaglandin E synthase-1 (mPGES-1). Our previous studies have …

Walnut (Juglans regia L.) is a food with food-medicine homology, whose derived protein
peptides have been shown to have anti-inflammatory activity in vitro. However, the effects …

The gut microbiota contributes to the pathophysiology of non-alcoholic fatty liver disease
(NAFLD). Histidine is a key energy source for the microbiota, scavenging it from the host. Its …

Beyond their conventional roles in intracellular energy production, some traditional
metabolites also function as extracellular messengers that activate cell-surface G-protein …

The vital role of probiotics in the food field has been widely recognized, and at the same
time, probiotics are gradually exhibiting surprising effects in the field of nutraceuticals …

The impact of carbohydrate quality, measured by the carbohydrate quality index (CQI), on
gut microbiota and health has been scarcely investigated. The aim of this study was to cross …