Biofilm dispersion

KP Rumbaugh, K Sauer - Nature Reviews Microbiology, 2020 - nature.com
The formation of microbial biofilms enables single planktonic cells to assume a multicellular
mode of growth. During dispersion, the final step of the biofilm life cycle, single cells egress …

Regulation of Biofilm Exopolysaccharide Biosynthesis and Degradation in Pseudomonas aeruginosa

LZ Ma, D Wang, Y Liu, Z Zhang… - Annual review of …, 2022 - annualreviews.org
Microbial communities enmeshed in a matrix of macromolecules, termed as biofilms, are the
natural setting of bacteria. Exopolysaccharide is a critical matrix component of biofilms …

Spatial transcriptomics of planktonic and sessile bacterial populations at single-cell resolution

D Dar, N Dar, L Cai, DK Newman - Science, 2021 - science.org
INTRODUCTION Microbial populations display heterogeneous gene expression profiles that
result in phenotypic differences between individual bacteria. This diversity can allow …

[HTML][HTML] Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies

LK Jennings, JE Dreifus, C Reichhardt, KM Storek… - Cell reports, 2021 - cell.com
In cystic fibrosis (CF) airways, Pseudomonas aeruginosa forms cellular aggregates called
biofilms that are thought to contribute to chronic infection. To form aggregates, P. aeruginosa …

[HTML][HTML] Pseudomonas aeruginosa biofilms and their partners in crime

M del Mar Cendra, E Torrents - Biotechnology advances, 2021 - Elsevier
Pseudomonas aeruginosa biofilms and the capacity of the bacterium to coexist and interact
with a broad range of microorganisms have a substantial clinical impact. This review focuses …

[HTML][HTML] The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix

D Passos da Silva, ML Matwichuk… - Nature …, 2019 - nature.com
Pseudomonas aeruginosa biofilms are composed of exopolysaccharides (EPS), exogenous
DNA, and proteins that hold these communities together. P. aeruginosa produces lectins …

[HTML][HTML] An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa

CJ Harding, M Bischoff, M Bergkessel… - Nature Chemical …, 2023 - nature.com
Pseudomonas aeruginosa is an opportunistic pathogen that causes serious illness,
especially in immunocompromised individuals. P. aeruginosa forms biofilms that contribute …

Surface sensing and adaptation in bacteria

BJ Laventie, U Jenal - Annual review of microbiology, 2020 - annualreviews.org
Bacteria thrive both in liquids and attached to surfaces. The concentration of bacteria on
surfaces is generally much higher than in the surrounding environment, offering bacteria …

[HTML][HTML] Confocal Laser Scanning Microscopy for Analysis of Pseudomonas aeruginosa Biofilm Architecture and Matrix Localization

C Reichhardt, MR Parsek - Frontiers in microbiology, 2019 - frontiersin.org
Most microbes can produce surface-associated or suspended aggregates called biofilms,
which are encased within a biopolymer-rich matrix. The biofilm matrix provides structural …

Substrate stiffness impacts early biofilm formation by modulating Pseudomonas aeruginosa twitching motility

S Gomez, L Bureau, K John, EN Chêne, D Débarre… - Elife, 2023 - elifesciences.org
Surface-associated lifestyles dominate in the bacterial world. Large multicellular assemblies,
called biofilms, are essential to the survival of bacteria in harsh environments and are …