One of the key features associated with the substantial increase in life expectancy for
individuals with CF is an elevated predisposition to cancer, firmly established by recent …

Growing numbers of translational genomics studies are based on the highly efficient and
versatile zebrafish (Danio rerio) vertebrate model. The increasing types of zebrafish models …

Foxj1a is necessary and sufficient to specify motile cilia. Using transcriptional studies and
slow-scan two-photon live imaging capable of identifying the number of motile and immotile …

How epithelial cell behaviors are coordinately regulated to sculpt tissue architecture is a
fundamental question in biology. Kupffer's vesicle (KV), a transient organ with a fluid-filled …

Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic
cause of end-stage renal failure in humans and results from germline mutations in PKD1 or …

Establishing left–right asymmetry is a fundamental process essential for arrangement of
visceral organs during development. In vertebrates, motile cilia-driven fluid flow in the left …

Polycystic kidney disease (PKD) proteins are trans-membrane proteins that have crucial
roles in many aspects of vertebrate development and physiology, including the development …

Reduction in the length of motile cilia in the zebrafish left–right organizer (LRO), also known
as Kupffer's vesicle, has a large impact on left–right development. Here we demonstrate …

摘要斑马鱼的肾单位结构, 功能和分子组成与高等哺乳动物后肾高度保守,
已广泛应用于肾脏领域的研究. 文章介绍了斑马鱼肾脏的基本生物学特征, 阐述了斑马鱼在肾脏 …

Delivering drugs to the brain has always remained a challenge for the research community
and physicians. The blood–brain barrier (BBB) acts as a major hurdle for delivering drugs to …