Molecular cascades of calcium homeostasis and signalling (Ca 2+ pumps, channels, cation
exchangers, and Ca 2+-binding proteins) emerged in prokaryotes and further developed at …

Abstract Structure-dynamic analysis of archaeal NCX (NCX_Mj) provided new insights into
the underlying mechanisms of ion selectivity, ion-coupled alternating access, ion occlusion …

Abstract Na+/Ca2+ exchangers use the Na+ electrochemical gradient across the plasma
membrane to extrude intracellular Ca2+ and play a central role in Ca2+ homeostasis. Here …

Na+/Ca2+ exchangers (NCXs) are ubiquitous membrane transporters with a key role in
Ca2+ homeostasis and signaling. NCXs mediate the bidirectional translocation of either Na+ …

The plasma-membrane homeostasis Na+/Ca2+ exchangers (NCXs) mediate Ca2+
extrusion/entry to dynamically shape Ca2+ signaling/in biological systems ranging from …

The plasma membrane (NCX) and mitochondrial (NCLX) Na+/Ca 2+ exchangers are
structurally related proteins, although they operate under strictly different ionic conditions …

The membrane-bound sodium–calcium exchanger (NCX) proteins shape Ca2+
homeostasis in many cell types, thus participating in a wide range of physiological and …

Secondary-active transporters catalyze the movement of myriad substances across all
cellular membranes, typically against opposing concentration gradients, and without …

Due to the neuroprotective role of the Na+/Ca2+ exchanger (NCX) isoforms NCX1 and
NCX3, we synthesized novel benzodiazepinone derivatives of the unique NCX activator …

In analogy with many other proteins, Na+/Ca2+ exchangers (NCX) adapt an inverted twofold
symmetry of repeated structural elements, while exhibiting a functional asymmetry by …