The body is exposed to foreign pathogens every day, but remarkably, most pathogens are
effectively cleared by the innate immune system without the need to invoke the adaptive …

There is an urgent need for new antimicrobial strategies for treating complex infections and
emerging pathogens. Human mesenchymal stromal cells (MSCs) are adult multipotent cells …

Innate immunity is based in pre-existing elements of the immune system that directly interact
with all types of microbes leading to their destruction or growth inhibition. Several elements …

Paracoccidioidomycosis (PCM) is an endemic mycosis in Latin America caused by the
dimorphic fungus Paracoccidioides brasiliensis. The pattern of the immune responses to P …

Invasive aspergillosis is a common opportunistic infection, causing> 50% mortality in
infected immunocompromised patients. The specific molecular mechanisms of the innate …

Oxylipins or oxidized fatty acids are a group of molecules found to play a role in signaling in
many different cell types. These fatty acid derivatives have ancient evolutionary origins as …

AIMS: Silibinin is the major active component of silymarin, a polyphenolic plant flavonoid
that has anti-inflammatory effects. The modulatory effect of silibinin on monocyte function …

The prevalence of fungal infections has increased in immunocompromised patients, leading
to millions of deaths annually. Arachidonic acid (AA) metabolites, such as eicosanoids, play …

Paracoccidioides brasiliensis is the agent of paracoccidioidomycosis, the most prevalent
deep mycosis in Latin America. Production of eicosanoids during fungal infections plays a …

Paracoccidioidomycosis (PCM) is a systemic mycosis, endemic in most Latin American
countries, especially in Brazil, whose etiologic agent is the thermodimorphic fungus of the …