Solute carrier (SLC) membrane transport proteins control essential physiological functions,
including nutrient uptake, ion transport, and waste removal. SLCs interact with several …

The human solute carriers (SLCs) comprise over 400 different transporters, organized into
65 families (http://slc. bioparadigms. org/) based on their sequence homology and transport …

Abstract γ-Aminobutyric acid (GABA) transporter 1 (GAT1) regulates neuronal excitation of
the central nervous system by clearing the synaptic cleft of the inhibitory neurotransmitter …

The serotonin transporter (SERT) terminates serotonergic signalling through the sodium-and
chloride-dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target …

Abstract Antidepressants targeting Na+/Cl−-coupled neurotransmitter uptake define a key
therapeutic strategy to treat clinical depression and neuropathic pain. However, identifying …

The human glycine transporter 1 (GlyT1) regulates glycine-mediated neuronal excitation
and inhibition through the sodium-and chloride-dependent reuptake of glycine,–. Inhibition …

Parkinsonism and attention deficit hyperactivity disorder (ADHD) are widespread brain
disorders that involve disturbances of dopaminergic signaling. The sodium-coupled …

Monoamine transporters (MATs) regulate neurotransmission via the reuptake of dopamine,
serotonin and norepinephrine from extra-neuronal regions and thus maintain …

The serotonin transporter (SERT) removes synaptic serotonin and is the target of anti-
depressant drugs. SERT adopts three conformations: outward-open, occluded, and inward …

The secondary active cation–chloride cotransporters (CCCs) utilize the existing Na+ and/or
K+ gradients to move Cl− into or out of cells. NKCC1 is an intensively studied member of the …