Interferons (IFNs) are antiviral cytokines that defend against viral infections by inducing the
expression of interferon-stimulated genes (ISGs). Interferon-inducible transmembrane …

Interferon-induced transmembrane proteins (IFITMs) are upregulated by interferons. They
are not only highly conserved in evolution but also structurally consistent and have almost …

Influenza virus pandemics are caused by viruses from animal reservoirs that adapt to
efficiently infect and replicate in human hosts. Here, we investigate whether Interferon …

Lesch–Nyhan syndrome (LN) is an is an X-linked recessive inborn error of metabolism that
arises from a deficiency of purine salvage enzyme hypoxanthine-guanine …

Influenza A virus (IAV) infection causes acute and often lethal inflammation in the lung. The
role of macrophages in this adverse inflammation is partially understood. The surfactant …

Mitapivat, a pyruvate kinase activator, shows great potential as a sickle cell disease (SCD)-
modifying therapy. The safety and efficacy of mitapivat as a long-term maintenance therapy …

BACKGROUND: Tetraspanin CD151 is highly expressed in endothelia and reinforces cell
adhesion, but its role in vascular inflammation remains largely unknown. METHODS: In vitro …

Zika virus (ZIKV), a member of the Flaviviridae family, is primarily transmitted through
mosquito bites, but can also spread via sexual contact and from mother to fetus. While often …

Influenza virus pandemics are caused by viruses from animal reservoirs that adapt to
efficiently infect and replicate in human hosts. Here, we investigated whether Interferon …

Here we investigated whether interferon induced transmembrane protein 3 (IFITM3), a key
antiviral protein deficient in certain human populations, affects interspecies adaptation of …