Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

Proteomics researchers today face an interesting challenge: how to choose among the
dozens of data processing and analysis pipelines available for converting tandem mass …

Site-specific characterization of glycosylation requires intact glycopeptide analysis, and
recent efforts have focused on how to best interrogate glycopeptides using tandem mass …

Glycosylation is a prevalent, yet heterogeneous modification with a broad range of
implications in molecular biology. This heterogeneity precludes enrichment strategies that …

Glycoproteomics is a powerful yet analytically challenging research tool. Software packages
aiding the interpretation of complex glycopeptide tandem mass spectra have appeared, but …

The extracellular matrix (ECM) is a complex assembly of hundreds of proteins forming the
architectural scaffold of multicellular organisms. In addition to its structural role, the ECM …

Intact glycopeptide identification has long been known as a key and challenging barrier to
the comprehensive and accurate understanding the role of glycosylation in an organism …

Growing implications of glycosylation in physiological occurrences and human disease have
prompted intensive focus on revealing glycomic perturbations through absolute and relative …

Here we present GlycanFinder, a database search and de novo sequencing tool for the
analysis of intact glycopeptides from mass spectrometry data. GlycanFinder integrates …

Modification of proteins by glycans plays a crucial role in mediating biological functions in
both healthy and diseased states. Mass spectrometry (MS) has emerged as the most …