The role of IL-6 in skin fibrosis and cutaneous wound healing

BZ Johnson, AW Stevenson, CM Prêle, MW Fear… - Biomedicines, 2020 - mdpi.com
The timely resolution of wound healing is critical for restoring the skin as a protective barrier.
The switch from a proinflammatory to a reparative microenvironment must be tightly …

[HTML][HTML] Innate immune memory in invertebrate metazoans: a critical appraisal

D Melillo, R Marino, P Italiani, D Boraschi - Frontiers in Immunology, 2018 - frontiersin.org
The ability of developing immunological memory, a characteristic feature of adaptive
immunity, is clearly present also in innate immune responses. In fact, it is well known that …

[PDF][PDF] GABA regulates IL-1β production in macrophages

J Fu, Z Han, Z Wu, Y Xia, G Yang, Y Yin, W Ren - Cell Reports, 2022 - cell.com
Neurotransmitters have been well documented to determine immune cell fates; however,
whether and how γ-amino butyric acid (GABA) shapes the function of innate immune cells is …

[HTML][HTML] The synaptic theory of memory: a historical survey and reconciliation of recent opposition

JJ Langille, RE Brown - Frontiers in systems neuroscience, 2018 - frontiersin.org
Trettenbrein has argued that the concept of the synapse as the locus of memory is outdated
and has made six critiques of this concept. In this article, we examine these six critiques and …

[HTML][HTML] Innate immune memory: time for adopting a correct terminology

D Boraschi, P Italiani - Frontiers in immunology, 2018 - frontiersin.org
The concept of innate immune memory, ie, a change in the reactivity in innate immune cells
previously exposed to various stimuli, is well known in plants, invertebrates and also in …

The role of the interleukin-1 family in complications of prematurity

EA Green, SP Garrick, B Peterson, PJ Berger… - International Journal of …, 2023 - mdpi.com
Preterm birth is a major contributor to neonatal morbidity and mortality. Complications of
prematurity such as bronchopulmonary dysplasia (BPD, affecting the lung), pulmonary …

[HTML][HTML] Macrophage secretory IL-1β promotes docetaxel resistance in head and neck squamous carcinoma via SOD2/CAT-ICAM1 signaling

CY Hsieh, CC Lin, YW Huang, JH Chen, YA Tsou… - JCI insight, 2022 - ncbi.nlm.nih.gov
Docetaxel (DTX) combined with cisplatin and 5-fluorouracil has been used as induction
chemotherapy for head and neck squamous cell carcinoma (HNSCC). However, the …

Aspartate metabolism facilitates IL-1β production in inflammatory macrophages

H Wang, X Zheng, B Liu, Y Xia, Z Xin, B Deng… - Frontiers in …, 2021 - frontiersin.org
Increasing evidence support that cellular amino acid metabolism shapes the fate of immune
cells; however, whether aspartate metabolism dictates macrophage function is still …

The NLRP3-inflammasome-caspase-1 pathway is upregulated in idiopathic pulmonary fibrosis and acute exacerbations and is inducible by apoptotic A549 cells

B Jäger, B Seeliger, O Terwolbeck… - Frontiers in …, 2021 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive disease harboring significant
morbidity and mortality despite recent advances in therapy. Regardless of disease severity …

Helicobacter pylori Infection of Primary Human Monocytes Boosts Subsequent Immune Responses to LPS

T Frauenlob, T Neuper, M Mehinagic… - Frontiers in …, 2022 - frontiersin.org
Infection with Helicobacter pylori (H. pylori) affects almost half of the world's population and
is a major cause of stomach cancer. Although immune cells react strongly to this gastric …