Joining S100 proteins and migration: for better or for worse, in sickness and in health

SR Gross, CGT Sin, R Barraclough… - Cellular and molecular life …, 2014 - Springer
The vast diversity of S100 proteins has demonstrated a multitude of biological correlations
with cell growth, cell differentiation and cell survival in numerous physiological and …

Aluminium and breast cancer: Sources of exposure, tissue measurements and mechanisms of toxicological actions on breast biology

PD Darbre, F Mannello, C Exley - Journal of inorganic biochemistry, 2013 - Elsevier
This review examines recent evidence linking exposure to aluminium with the aetiology of
breast cancer. The human population is exposed to aluminium throughout daily life …

Cancer‐associated fibroblasts and epithelial‐mesenchymal transition in metastatic oral tongue squamous cell carcinoma

M Vered, D Dayan, R Yahalom… - … journal of cancer, 2010 - Wiley Online Library
We examined cancer‐associated fibroblasts (CAFs) and a panel of immunohistochemical
markers of epithelial‐mesenchymal transition (EMT) in 19 pair‐matched oral tongue …

S100A4 interacts with p53 in the nucleus and promotes p53 degradation

LM Orre, E Panizza, VO Kaminskyy, E Vernet… - Oncogene, 2013 - nature.com
S100A4 is a small calcium-binding protein that is commonly overexpressed in a range of
different tumor types, and it is widely accepted that S100A4 has an important role in the …

Depletion of the aryl hydrocarbon receptor in MDA-MB-231 human breast cancer cells altered the expression of genes in key regulatory pathways of cancer

G Goode, S Pratap, SE Eltom - PloS one, 2014 - journals.plos.org
The aryl hydrocarbon receptor (AhR), a transcription factor that is best known for its role in
mediating the toxic responses elicited by poly aromatic hydrocarbons as well as many other …

S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE)

Q Jin, H Chen, A Luo, F Ding, Z Liu - PloS one, 2011 - journals.plos.org
S100A14 is an EF-hand containing calcium-binding protein of the S100 protein family that
exerts its biological effects on different types of cells. However, exact extracellular roles of …

[PDF][PDF] The importance of Ca2+/Zn2+ signaling S100 proteins and RAGE in translational medicine

E Leclerc, CW Heizmann - Front Biosci (Schol Ed), 2011 - article.imrpress.com
Introduction 3. General features of S100 proteins 4. The receptor for advanced glycation
endproducts (RAGE) 5. Structures and functions of S100 proteins and RAGE: association …

Aluminium and human breast diseases

PD Darbre, D Pugazhendhi, F Mannello - Journal of Inorganic Biochemistry, 2011 - Elsevier
The human breast is exposed to aluminium from many sources including diet and personal
care products, but dermal application of aluminium-based antiperspirant salts provides a …

[HTML][HTML] S100 proteins: Diagnostic and prognostic biomarkers in laboratory medicine

CW Heizmann - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2019 - Elsevier
S100 proteins are members of the superfamily of Ca 2+-binding proteins characterized by
the specific Ca 2+-binding motif, the EF-hand. Proteins of this superfamily are of clinical use …

S100P dissociates myosin IIA filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration

M Du, G Wang, TM Ismail, S Gross, DG Fernig… - Journal of Biological …, 2012 - ASBMB
S100 proteins promote cancer cell migration and metastasis. To investigate their roles in the
process of migration we have constructed inducible systems for S100P in rat mammary and …