Drug-induced liver injury (DILI) is a rare but severe adverse drug reaction seen in
pharmacotherapy and a major cause of postmarketing drug withdrawals. Advances in …

MicroRNAs (MiRNAs) are endogenous non-coding small RNA molecules that regulate gene
expression in plants, animals and some viruses. Both normal and pathological liver …

Liver fibrosis is characterized by the accumulation of extracellular matrix (ECM) resulting in
the formation of fibrous scars. In the clinic, liver biopsies are the standard diagnostic method …

A major challenge in drug development is safety and toxicity concerns due to drug side
effects. One such side effect, drug-induced liver injury (DILI), is considered a primary factor …

Propylene glycol ethers (PGEs) are organic solvents commonly found as technical grade on
the commercial market, as mixtures of secondary (α‐isomer) and primary (β‐isomer …

3D cell culture systems are widely used to study disease mechanisms and therapeutic
interventions. Multicellular liver microtissues (MTs) comprising HepaRG, hTERT-HSC and …

Organ toxicities or dose-limiting toxicities, identified in nonclinical animal toxicology studies,
can be addressed with mechanistic translational models. To increase throughput, models …

A major challenge in drug development is safety and toxicity concerns due to drug
sideeffects. One such side effect, drug-induced liver injury (DILI), is considered a …

Liver fibrosis is characterized by the accumulation of extracellular matrix (ECM) resulting in
the formation of fibrous scars. In the clinic, liver biopsies are the standard diagnostic method …