Appetitive motivation and incentive states are essential functions sustained by a common
emotional brain process, the SEEKING disposition, which drives explorative and approach …

One well accepted functional feature of the parkinsonian state is the recording of enhanced
beta oscillatory activity in the basal ganglia. This has been demonstrated in patients with …

Synchronized oscillatory neuronal activity in the beta frequency range has been observed in
the basal ganglia of Parkinson's disease patients and hypothesized to be antikinetic. The …

Background Long‐term use of levodopa for Parkinson's disease (PD) treatment is often
hindered by development of motor complications, including levodopa‐induced dyskinesia …

Neuroinflammation and apoptosis in the dopaminergic neurons of substantia nigra play an
important role in the pathogenesis of experimental and clinical Parkinson's disease (PD) …

Glial cell line-derived neurotrophic factor (GDNF) is the most potent neuroprotective agent
tested in cellular and animal models of Parkinson's disease (PD). However, CNS delivery of …

It is well established that parkinsonian syndrome is associated with alterations in the
temporal pattern of neuronal activity and local field potentials in the basal ganglia (BG). An …

Parkinson's disease is a common neurodegenerative disease characterized by a widely
variety of motor and non-motor symptoms. While the motor deficits are only visible following …

The superior efficacy of atypical vs. classical antipsychotic drugs to treat negative symptoms
and cognitive deficits in schizophrenia appears related to their ability to enhance …

Currently existing behavioral measures for motor impairments in rodent models with bilateral
dopamine depletion have demonstrated to be difficult to assess due to the degree of task …