Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation …

Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

Osteoarthritis is the most common musculoskeletal disease and the leading cause of
disability globally. Here, we performed a genome-wide association study for osteoarthritis …

Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …

Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and
obesity associated (FTO) gene are associated obesity traits in genome-wide association …

Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

There is an increasing awareness on the importance in identifying early phases of the
degenerative processes in knee osteoarthritis (OA), the crucial period of the disease when …

Abstract The Estonian Biobank cohort is a volunteer-based sample of the Estonian resident
adult population (aged≥ 18 years). The current number of participants—close to 52000 …

Abstract The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of
Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic …