Immunomodulatory effects mediated by serotonin

R Arreola, E Becerril-Villanueva… - Journal of …, 2015 - Wiley Online Library
Serotonin (5‐HT) induces concentration‐dependent metabolic effects in diverse cell types,
including neurons, entherochromaffin cells, adipocytes, pancreatic beta‐cells, fibroblasts …

[HTML][HTML] Lipid interaction sites on channels, transporters and receptors: recent insights from molecular dynamics simulations

G Hedger, MSP Sansom - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
Lipid molecules are able to selectively interact with specific sites on integral membrane
proteins, and modulate their structure and function. Identification and characterization of …

Membrane cholesterol modulates oligomeric status and peptide-membrane interaction of severe acute respiratory syndrome coronavirus fusion peptide

G Meher, S Bhattacharjya… - The Journal of Physical …, 2019 - ACS Publications
The N-terminal fusion peptide (residues 770–788) of an S2 glycoprotein of the severe acute
respiratory syndrome coronavirus (SARS-CoV), exposed upon receptor binding, is crucial …

Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking

U Renner, A Zeug, A Woehler, M Niebert… - Journal of cell …, 2012 - journals.biologists.com
Serotonin receptors 5-HT1A and 5-HT7 are highly coexpressed in brain regions implicated
in depression. However, their functional interaction has not been established. In the present …

DNA binding triggers tetramerization of the glucocorticoid receptor in live cells

DM Presman, S Ganguly, RL Schiltz… - Proceedings of the …, 2016 - National Acad Sciences
Transcription factors dynamically bind to chromatin and are essential for the regulation of
genes. Although a large percentage of these proteins appear to self-associate to form …

Cholesterol modulates the dimer interface of the β2-adrenergic receptor via cholesterol occupancy sites

X Prasanna, A Chattopadhyay, D Sengupta - Biophysical journal, 2014 - cell.com
The β 2-adrenergic receptor is an important member of the G-protein-coupled receptor
(GPCR) superfamily, whose stability and function are modulated by membrane cholesterol …

A molecular sensor for cholesterol in the human serotonin1A receptor

GA Kumar, P Sarkar, TM Stepniewski, M Jafurulla… - Science …, 2021 - science.org
The function of several G protein–coupled receptors (GPCRs) exhibits cholesterol sensitivity.
Cholesterol sensitivity of GPCRs could be attributed to specific sequence and structural …

[HTML][HTML] Molecular dynamics simulations of GPCR–cholesterol interaction: An emerging paradigm

D Sengupta, A Chattopadhyay - Biochimica et Biophysica Acta (BBA) …, 2015 - Elsevier
G protein-coupled receptors (GPCRs) are the largest class of molecules involved in signal
transduction across cell membranes and represent major targets in the development of …

Allosteric modulation of GPCRs of class A by cholesterol

J Jakubík, EE El-Fakahany - International journal of molecular sciences, 2021 - mdpi.com
G-protein coupled receptors (GPCRs) are membrane proteins that convey extracellular
signals to the cellular milieu. They represent a target for more than 30% of currently …

Interplay between Serotonin 5‐HT1A and 5‐HT7 Receptors in Depressive Disorders

VS Naumenko, NK Popova, E Lacivita… - CNS neuroscience & …, 2014 - Wiley Online Library
Summary Serotonin (5‐hydroxytryptamine or 5‐HT) is an important neurotransmitter
regulating a wide range of physiological and pathological functions via activation of …