For nearly 50 years the proximal tubule (PT) has been known to reabsorb, process, and
either catabolize or transcytose albumin from the glomerular filtrate. Innovative techniques …

The fractional clearance of proteins as measured in healthy human subjects increases
10,000–100,000-fold when studied in nephrotic patients. This remarkable increase cannot …

Background The kidney is considered to be a structurally stable organ with limited baseline
cellular turnover. Nevertheless, single cells must be constantly replaced to conserve the …

Intravital multiphoton microscopy is widely used to assess the structure and function of
organs in live animals. Although different tissues vary in their accessibility for intravital …

The kidney is a complex and dynamic organ with over 40 cell types, and tremendous
structural and functional diversity. Intravital multi-photon microscopy, development of …

Albuminuria is a hallmark of kidney diseases of various aetiologies and an unambiguous
symptom of the compromised integrity of the glomerular filtration barrier. Furthermore, there …

Intravital multiphoton microscopy of the kidney is a powerful technique to study alterations in
tissue morphology and function simultaneously in the living animal and represents a …

Intravital multiphoton microscopy has empowered investigators to study dynamic cell and
subcellular processes in vivo within normal and disease organs. Advances in hardware …

Together with endothelial cells and the glomerular basement membrane, podocytes form the
size-specific filtration barrier of the glomerulus with their interdigitating foot processes. Since …

Intravital microscopy, microscopy of living animals, is a powerful research technique that
combines the resolution and sensitivity found in microscopic studies of cultured cells with the …