Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …

The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers
in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the …

Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

Ischemia reperfusion (IR), present in myocardial infarction or extremity injuries, is a major
clinical issue and leads to substantial tissue damage. Molecular mechanisms underlying IR …

Mitochondrial respiration results in an electrochemical proton gradient, or protonmotive force
(pmf), across the mitochondrial inner membrane. The pmf is a form of potential energy …

Ischemic preconditioning renders the heart resistant to infarction from ischemia/reperfusion.
Over the past two decades a great deal has been learned about preconditioning's …

Aims Innate mechanisms of inter-organ protection underlie the phenomenon of remote
ischaemic preconditioning (RPc) in which episode (s) of ischaemia and reperfusion in …

Background—Transient (low-conductance) opening of the mitochondrial permeability
transition pore (mPTP) may limit mitochondrial calcium load and mediate mitochondrial …