Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are
critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors …

Recent advances in mitochondrial biology have revealed the high diversity and complexity
of proteolytic enzymes that regulate mitochondrial function. We have classified mitochondrial …

Nonalcoholic fatty liver disease (NAFLD) progresses to nonalcoholic steatohepatitis (NASH)
in response to elevated endoplasmic reticulum (ER) stress. Whereas the onset of simple …

The improper distribution of chromosomes during mitosis compromises cellular functions
and can reduce cellular fitness or contribute to malignant transformation. As a …

The complex process of apoptosis is orchestrated by caspases, a family of cysteine
proteases with unique substrate specificities. Accumulating evidence suggests that cell …

Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of
highly regulated processes. Radiation-induced tumor cell death has been studied …

Key structural and catalytic features are conserved across the entire family of cysteine-
dependent aspartate-specific proteases (caspases). Of the caspases involved in apoptosis …

The granzyme B-induced cell death has been traditionally viewed as a primary mechanism
that is used by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells to eliminate …

NVP-BEZ235 is a dual PI3K/mTOR inhibitor currently in phase I clinical trials. We profiled
this compound against a panel of breast tumor cell lines to identify the patient populations …

Both exogenous and endogenous agents are a threat to DNA integrity. Exogenous
environmental agents such as ultraviolet (UV) and ionizing radiation, genotoxic chemicals …