[HTML][HTML] Molecular mechanisms of ischemia and glutamate excitotoxicity
Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …
Bioactive human Alzheimer brain soluble Aβ: pathophysiology and therapeutic opportunities
The accumulation of amyloid-β protein (Aβ) plays an early role in the pathogenesis of
Alzheimer's disease (AD). The precise mechanism of how Aβ accumulation leads to synaptic …
Alzheimer's disease (AD). The precise mechanism of how Aβ accumulation leads to synaptic …
Glutamate indicators with improved activation kinetics and localization for imaging synaptic transmission
The fluorescent glutamate indicator iGluSnFR enables imaging of neurotransmission with
genetic and molecular specificity. However, existing iGluSnFR variants exhibit low in vivo …
genetic and molecular specificity. However, existing iGluSnFR variants exhibit low in vivo …
α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis
Background The accumulation of α-synuclein (α-syn), an essential step in PD development
and progression, is observed not only in neurons but also in glia, including astrocytes. The …
and progression, is observed not only in neurons but also in glia, including astrocytes. The …
Ceftriaxone as a novel therapeutic agent for hyperglutamatergic states: Bridging the gap between preclinical results and clinical translation
OA Abulseoud, F Alasmari, AM Hussein… - Frontiers in …, 2022 - frontiersin.org
Dysregulation of glutamate homeostasis is a well-established core feature of
neuropsychiatric disorders. Extracellular glutamate concentration is regulated by glutamate …
neuropsychiatric disorders. Extracellular glutamate concentration is regulated by glutamate …
The purinergic P2X7 receptor as a target for adjunctive treatment for drug-refractory epilepsy
D Thakku Sivakumar, K Jain, N Alfehaid… - International Journal of …, 2024 - mdpi.com
Epilepsy is one of the most common neurological diseases worldwide. Anti-seizure
medications (ASMs) with anticonvulsants remain the mainstay of epilepsy treatment …
medications (ASMs) with anticonvulsants remain the mainstay of epilepsy treatment …
Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism
It is well established that glutamate plays an important role in drug-induced and cue-induced
reinstatement of drug seeking. However, the role of glutamate in drug reward is unclear. In …
reinstatement of drug seeking. However, the role of glutamate in drug reward is unclear. In …
Asymmetric dysregulation of glutamate dynamics across the synaptic cleft in a mouse model of Alzheimer's disease
Most research on glutamate spillover focuses on the deleterious consequences of
postsynaptic glutamate receptor overactivation. However, two decades ago, it was noted that …
postsynaptic glutamate receptor overactivation. However, two decades ago, it was noted that …
Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models
K Ritter, P Somnuke, L Hu, EV Griemert… - BMC neuroscience, 2024 - Springer
TBI is a leading cause of death and disability in young people and older adults worldwide.
There is no gold standard treatment for TBI besides surgical interventions and symptomatic …
There is no gold standard treatment for TBI besides surgical interventions and symptomatic …
Drug repurposing for neurodegenerative diseases.
H Shukla, D John, S Banerjee… - Progress in Molecular …, 2024 - europepmc.org
Neurodegenerative diseases (NDDs) are neuronal problems that include the brain and
spinal cord and result in loss of sensory and motor dysfunction. Common NDDs include …
spinal cord and result in loss of sensory and motor dysfunction. Common NDDs include …