DNA replication and transcription occur in all living cells across all domains of life. Both
essential processes occur simultaneously on the same template, leading to conflicts …

Ribosomal DNA (rDNA) repeats harbor ribosomal RNA (rRNA) genes and intergenic
spacers (IGS). RNA polymerase (Pol) I transcribes rRNA genes yielding rRNA components …

Maintenance of genome stability is of paramount importance for the survival of an organism.
However, genomic integrity is constantly being challenged by various endogenous and …

Current models suggest that DNA double-strand breaks (DSBs) can move to the nuclear
periphery for repair. It is unclear to what extent human DSBs display such repositioning …

Simple Summary Genomic instability is an important feature of cancer, including multiple
myeloma, which is the second most common hematological malignancy. There are several …

In this review, we discuss the long-known problem of tissue-specific carcinogenesis in
BRCA1 and BRCA2 mutation carriers: while the genes are expressed ubiquitously …

ABSTRACT Purpose Transcription-replication conflicts (TRCs) are a major source of
endogenous replication stress in cancer. We previously discovered that pancreatic ductal …

DNA replication and transcription occur in all living cells across all domains of life. Both
essential processes occur simultaneously, on the same template, leading to conflicts …

Deregulated expression of MYC oncoproteins is a driving event in many human cancers.
Therefore, understanding and targeting MYC protein-driven mechanisms in tumor biology …