Microfluidic organs-on-chips
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …
methods that contains continuously perfused chambers inhabited by living cells arranged to …
Single‐cell mass spectrometry approaches to explore cellular heterogeneity
L Zhang, A Vertes - Angewandte Chemie International Edition, 2018 - Wiley Online Library
Compositional diversity is a fundamental property in cell populations. Single‐cell analysis
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …
A liver-on-a-chip platform with bioprinted hepatic spheroids
The inadequacy of animal models in correctly predicting drug and biothreat agent toxicity in
humans has resulted in a pressing need for in vitro models that can recreate the in vivo …
humans has resulted in a pressing need for in vitro models that can recreate the in vivo …
[HTML][HTML] The relevance of using 3D cell cultures, in addition to 2D monolayer cultures, when evaluating breast cancer drug sensitivity and resistance
S Breslin, L O'Driscoll - Oncotarget, 2016 - ncbi.nlm.nih.gov
Solid tumours naturally grow in 3D wherein the spatial arrangement of cells affects how they
interact with each other. This suggests that 3D cell culture may mimic the natural in vivo …
interact with each other. This suggests that 3D cell culture may mimic the natural in vivo …
Culture and functional characterization of human hepatoma HepG2 cells
MT Donato, L Tolosa, MJ Gómez-Lechón - Protocols in in vitro hepatocyte …, 2015 - Springer
Hepatoma cell lines are frequently used as in vitro alternatives to primary human
hepatocytes. Cell lines are characterized by their unlimited life span, stable phenotype, high …
hepatocytes. Cell lines are characterized by their unlimited life span, stable phenotype, high …
Liver 'organ on a chip'
The liver plays critical roles in both homeostasis and pathology. It is the major site of drug
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
metabolism in the body and, as such, a common target for drug-induced toxicity and is …
A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies
SC Ramaiahgari, MW Den Braver, B Herpers… - Archives of …, 2014 - Springer
Immortalized hepatocyte cell lines show only a weak resemblance to primary hepatocytes in
terms of gene expression and function, limiting their value in predicting drug-induced liver …
terms of gene expression and function, limiting their value in predicting drug-induced liver …
Organ-on-a-chip platforms for studying drug delivery systems
Novel microfluidic tools allow new ways to manufacture and test drug delivery systems.
Organ-on-a-chip systems—microscale recapitulations of complex organ functions—promise …
Organ-on-a-chip systems—microscale recapitulations of complex organ functions—promise …
In vitro and in vivo models of non-alcoholic fatty liver disease: a critical appraisal
PA Soret, J Magusto, C Housset… - Journal of clinical medicine, 2020 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD), including non-alcoholic fatty liver (NAFL) and non-
alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and …
alcoholic steatohepatitis (NASH), represents the hepatic manifestation of obesity and …
Microfluidics in nanoparticle drug delivery; From synthesis to pre-clinical screening
Microfluidic technologies employ nano and microscale fabrication techniques to develop
highly controllable and reproducible fluidic microenvironments. Utilizing microfluidics, lead …
highly controllable and reproducible fluidic microenvironments. Utilizing microfluidics, lead …