Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Breast cancer is associated with the second highest cancer-associated deaths worldwide.
Therefore, understanding the key events that determine breast cancer progression …

Animal experiments remain essential to understand the fundamental mechanisms
underpinning malignancy and to discover improved methods to prevent, diagnose and treat …

Metastatic disease is the primary cause of death for most cancer patients. Complex and
redundant pathways involving the tumor cell and the microenvironment mediate tumor …

Genome-wide association studies (GWASs) have identified numerous loci that influence risk
for psychiatric diseases. Genetically engineered mice are often used to characterize genes …

The translation of basic research into improved therapies for breast cancer patients requires
relevant preclinical models that incorporate spontaneous metastasis. We have completed a …

Metastasis, the spread of malignant cells from a primary tumor to distant sites, poses the
biggest problem to cancer treatment and is the main cause of death of cancer patients. It …

Metastasis can be viewed as an evolutionary process, culminating in the prevalence of rare
tumour cells that overcame stringent physiological barriers as they separated from their …

Despite recognizing the devastating consequences of metastasis, we are not yet able to
effectively treat cancer that has spread to vital organs. The inherent complexity of genomic …

Metastasis, the spread of a tumor from its primary site to other parts of the body, continues to
be the most significant problem in the field of cancer. Patients who present with metastatic …