Autosomal dominant polycystic kidney disease (ADPKD) affects an estimated 1 in 1,000
people and slowly progresses to end-stage renal disease (ESRD) in about half of these …

The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many
pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we …

Cancer cell lines have contributed immensely in understanding the complex physiology of
cancers. They are excellent material for studies as they offer homogenous samples without …

Although alternative splicing (AS) drives transcriptional responses and cellular adaptation to
environmental stresses, its contributions in organ transplantation have not been …

Regulatory T (Treg) cells induce an immunosuppressive microenvironment that is a major
obstacle for successful tumor immunotherapy. Dissecting the regulatory mechanisms …

Macrophage effector function is dynamic in nature and largely dependent on not only the
type of immunological challenge but also the tissue-specific environment and …

Stem cells and the niche in which they reside feature a complex microenvironment with
tightly regulated homeostasis, cell-cell interactions and dynamic regulation of metabolism. A …

Patients with severe COVID-19 infection exhibit a low level of oxygen in affected tissue and
blood. To understand the pathophysiology of COVID-19 infection, it is therefore necessary to …

Cellular senescence affects many physiological and pathological processes and is
characterized by durable cell cycle arrest, an inflammatory secretory phenotype and …

There is increasing interest in therapeutically exploiting metabolic differences between
normal and cancer cells. We show that kinase inhibitors (KIs) and biguanides synergistically …