Alternative splicing is one of the most important mechanisms to generate a large number of
mRNA and protein isoforms from the surprisingly low number of human genes. Unlike …

In 1991 a new type of G-protein-coupled receptor (GPCR) was cloned, the type 1a
metabotropic glutamate (mGlu) receptor, which, despite possessing the defining seven …

G protein-coupled receptors (GPCRs) constitute a superfamily of cell-surface receptors
which share a common topology of seven transmembrane domains and modulate a variety …

Almost 25 years after the first report that glutamate can activate receptors coupled to
heterotrimeric G-proteins, tremendous progress has been made in the field of metabotropic …

Substance P exerts its various biochemical effects mainly via interactions through neurokinin‐
1 receptors (NK1). Recently, the NK1 receptor has attracted considerable interest for its …

Arginine‐based endoplasmic reticulum (ER)‐localization signals are sorting motifs that are
involved in the biosynthetic transport of multimeric membrane proteins. After their discovery …

Neurons are highly polarized cells whose dendrites and axons extend long distances from
the cell body to form synapses that mediate neuronal communication. The trafficking of …

The plethora of functions of glutamate in the brain are mediated by the complementary
actions of ionotropic and metabotropic glutamate receptors (mGluRs). The ionotropic …

Background: Arginine-based endoplasmic reticulum (ER) localization signals are involved in
the heteromultimeric assembly of membrane protein complexes like ATP-sensitive …

G protein-coupled receptors (GPCRs) modulate diverse physiological and behavioral
signaling pathways by virtue of changes in receptor activation and inactivation states …