SOX4 is an essential developmental transcription factor that regulates stemness,
differentiation, progenitor development, and multiple developmental pathways including …

Dysregulation of transcription factors is one of the common problems in the pathogenesis of
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …

Radiotherapy is one of the most effective approaches to achieve tumor control in cancer
patients, although healthy tissue injury due to off-target radiation exposure can occur. In this …

Gastric cancer (GC) is a leading cause of death worldwide. GC is the third-most common
cause of cancer-related death after lung and colorectal cancer. It is also the fifth-most …

Cancer stem cells (CSCs) may contribute to an increased risk of recurrence in ovarian
cancer (OC). Further research is needed to identify associations between CSC markers and …

Most retinoblastomas develop from maturing cone precursors in response to biallelic RB1
loss and are dependent on cone maturation-related signaling. Additionally,∼ 2% lack RB1 …

The extraordinary plasticity of glioma cells allows them to contribute to different cellular
compartments in tumor vessels, reinforcing the vascular architecture. It was recently …

Despite the development of cancer therapies, the success of most treatments has been
impeded by drug resistance. The crucial role of tumor cell plasticity has emerged recently in …

Many epithelial compartments undergo constitutive renewal in homeostasis but activate
unique regenerative responses following injury. The clear corneal epithelium is crucial for …

The SOX9 transcription factor ensures proper tissue development and homeostasis and has
been implicated in promoting tumor progression. However, the role of SOX9 as a driver of …