Associations between statins and adverse events in primary prevention of cardiovascular disease: systematic review with pairwise, network, and dose-response meta …

T Cai, L Abel, O Langford, G Monaghan, JK Aronson… - Bmj, 2021 - bmj.com
Objective To assess the associations between statins and adverse events in primary
prevention of cardiovascular disease and to examine how the associations vary by type and …

Primary prevention of cardiovascular disease: A review of contemporary guidance and literature

J Stewart, G Manmathan… - JRSM cardiovascular …, 2017 - journals.sagepub.com
Cardiovascular disease is a significant and ever-growing problem in the United Kingdom,
accounting for nearly one-third of all deaths and leading to significant morbidity. It is also of …

[HTML][HTML] Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials

C Reith, C Baigent, L Blackwell, J Emberson, E Spata… - The Lancet, 2022 - thelancet.com
Background Statin therapy is effective for the prevention of atherosclerotic cardiovascular
disease and is widely prescribed, but there are persisting concerns that statin therapy might …

[PDF][PDF] 2016 European Guidelines on cardiovascular disease prevention in clinical practice

MF Piepoli, AW Hoes, S Agewall… - Polish Heart …, 2016 - journals.viamedica.pl
2.3. 9. Wnioski................................................ 838 2.4. Inne markery ryzyka.......................................
. 840 2.4. 1. Wywiad rodzinny/(epi) genetyka............ 840 2.4. 1.1. Wywiad …

[PDF][PDF] 2016 ESC/EAS guidelines for the management of dyslipidaemias

AL Catapano, I Graham, G De Backer… - Polish Heart …, 2016 - journals.viamedica.pl
5.1. Wpływ stylu życia na stężenie cholesterolu całkowitego i stężenie cholesterolu frakcji
lipoprotein o małej gęstości................................ 1259 5.2. Wpływ stylu życia na stężenie …

Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials

E Herrett, E Williamson, K Brack, D Beaumont… - bmj, 2021 - bmj.com
Objective To establish the effect of statins on muscle symptoms in people who had
previously reported muscle symptoms when taking statins. Design Series of randomised …

Why most clinical research is not useful

JPA Ioannidis - PLoS medicine, 2016 - journals.plos.org
Why Most Clinical Research Is Not Useful | PLOS Medicine Skip to main content
Advertisement PLOS Medicine Browse Current Issue Journal Archive Special Issues …

Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid-Lowering Arm (ASCOT-LLA) …

A Gupta, D Thompson, A Whitehouse, T Collier… - The Lancet, 2017 - thelancet.com
Background In blinded randomised controlled trials, statin therapy has been associated with
few adverse events (AEs). By contrast, in observational studies, larger increases in many …

Misrepresentation and distortion of research in biomedical literature

I Boutron, P Ravaud - … of the National Academy of Sciences, 2018 - National Acad Sciences
Publication in peer-reviewed journals is an essential step in the scientific process. However,
publication is not simply the reporting of facts arising from a straightforward analysis thereof …

Interpretation of the evidence for the efficacy and safety of statin therapy

R Collins, C Reith, J Emberson, J Armitage, C Baigent… - The Lancet, 2016 - thelancet.com
This Review is intended to help clinicians, patients, and the public make informed decisions
about statin therapy for the prevention of heart attacks and strokes. It explains how the …