Research progress of contrast agents for bacterial infection imaging in vivo

Y Zhang, M Hao, L Li, Q Luo, S Deng, Y Yang… - TrAC Trends in …, 2023 - Elsevier
Accurate and sensitive detection of pathogenic bacteria are crucial for effectively treating
bacterial infection and reducing mortality caused by bacterial infection. Contrast agent …

Kit-based synthesis of 2-deoxy-2-[18F]-fluoro-d-sorbitol for bacterial imaging

F Mota, P De Jesus, SK Jain - Nature protocols, 2021 - nature.com
Clinically available imaging tools for diagnosing infections rely on structural changes in the
affected tissues. They therefore lack specificity and cannot differentiate between oncologic …

Enzyme‐activated, chemiluminescent siderophore‐dioxetane probes enable the selective and highly sensitive detection of bacterial pathogens

C Peukert, S Popat Gholap, O Green… - Angewandte Chemie …, 2022 - Wiley Online Library
The sensitive detection of bacterial infections is a prerequisite for their successful treatment.
The use of a chemiluminescent readout was so far hampered by an insufficient probe …

68Ga-labelled desferrioxamine-B for bacterial infection imaging

M Petrik, E Umlaufova, V Raclavsky, A Palyzova… - European journal of …, 2021 - Springer
Purpose With the increase of especially hospital-acquired infections, timely and accurate
diagnosis of bacterial infections is crucial for effective patient care. Molecular imaging has …

Optimization of Artificial Siderophores as 68Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections

C Peukert, LNB Langer, SM Wegener… - Journal of Medicinal …, 2021 - ACS Publications
The diagnosis of bacterial infections at deep body sites benefits from noninvasive imaging of
molecular probes that can be traced by positron emission tomography (PET). We specifically …

Biological Evaluation of d-[18F]Fluoroalanine and d-[18F]Fluoroalanine-d3 as Positron Emission Tomography Imaging Tracers for Bacterial Infection

K Li, J Tolentino Collado, JA Marden… - Journal of Medicinal …, 2024 - ACS Publications
d-Amino acids such as d-alanine are substrates for bacterial peptidoglycan biosynthesis and
are selectively taken up by bacteria and not mammalian cells. Consequently, d-amino acid …

[HTML][HTML] 11C-Para-aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and humans

AA Ordonez, MFL Parker, RJ Miller, D Plyku… - JCI insight, 2022 - ncbi.nlm.nih.gov
Tools for noninvasive detection of bacterial pathogens are needed but are not currently
available for clinical use. We have previously shown that para-aminobenzoic acid (PABA) …

Bacteria‐Targeted MRI Probe‐Based Imaging Bacterial Infection and Monitoring Antimicrobial Therapy In Vivo

L Li, P Gu, M Hao, X Xiang, Y Feng, X Zhu, Y Song… - Small, 2021 - Wiley Online Library
Despite the significant advances of imaging techniques nowadays, accurate diagnosis of
bacterial infections and real‐time monitoring the efficacy of antibiotic therapy in vivo still …

Infection imaging: focus on new tracers?

W Roll, A Faust, S Hermann… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Infections account for relevant morbidity and mortality, especially if the cardiovascular
system is affected. Clinical manifestations are often unspecific, resulting in a challenging …

[68Ga]Ga-Schizokinen, a Potential Radiotracer for Selective Bacterial Infection Imaging

A Akter, G Firth, AMF Darwesh, MS Cooper… - ACS infectious …, 2024 - ACS Publications
Gallium-68-labeled siderophores as radiotracers have gained interest for the development
of in situ infection-specific imaging diagnostics. Here, we report radiolabeling, in vitro …