The review begins with a concise description of the principles of phase separation. This is
followed by a comprehensive section on phase separation of chromatin, in which we recount …

The cell nucleus stores the genetic material essential for life, and provides the environment
for transcription, maintenance, and replication of the genome. Moreover, the nucleoplasm is …

Viscoelasticity and its alteration in time and space has turned out to act as a key element in
fundamental biological processes in living systems, such as morphogenesis and motility …

Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence
suggests that characteristic differences are present in the nuclear mechanics and …

The role of the spatial organization of chromosomes in directing transcription remains an
outstanding question in gene regulation. Here, we analyze two recent single-cell imaging …

Chromatin regulatory processes physically take place in the environment of the cell nucleus,
which is filled with the chromosomes and a plethora of smaller biomolecules. The nucleus …

Analyses of ancient DNA typically involve sequencing the surviving short oligonucleotides
and aligning to genome assemblies from related, modern species. Here, we report that skin …

Dynamic chromatin organization instantly influences DNA accessibility through modulating
local macromolecular density and interactions, driving changes in transcription activities …

The mechanism of self-organization of chromatin subcompartments on the 0.1–1 μm scale
and their impact on genome-associated activities has long been a key aspect of research on …

Beyond the critical role of cell nuclei in gene expression and DNA replication, they also have
a significant influence on cell mechanosensation and migration. Nuclear stiffness can impact …