Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …

Abstract Purpose of Review Successful treatment of cancer can be hampered by the
attendant risk of cardiotoxicity, manifesting as cardiomyopathy, left ventricle systolic …

Background: The concept of chemical agents having properties that confer potential hazard
called key characteristics (KCs) was first developed to identify carcinogenic hazards …

Membrane transporters play a key role in determining the pharmacokinetic profile,
therapeutic safety, and efficacy of many chemotherapeutic drugs by regulating cellular influx …

OBJECTIVE: Methotrexate (MTX) is one of the most commonly used anti-cancer drugs for
various types of neoplasms. It is associated with multiple cytotoxic effects including …

Mitochondrial dysfunction plays a key role in doxorubicin-induced cardiotoxicity (DIC). In this
proof-of-principle study, we investigated whether PET mapping of cardiac membrane …

Adenosine triphosphate binding cassette (ABC) transporters are a broad family of
membrane protein complexes that use energy to transport molecules across cells and/or …

In cardiotoxicity, PET/MR affords an accurate evaluation of cardiovascular morphology,
function, and also multi-parametric tissue characterization. A composite of several cardiac …

Reactive oxygen species (ROS) are generated during normal cellular energy production
and play a critical role in maintaining cellular function. However, excessive ROS can …

Cancer and cardiovascular disease are the most significant causes of morbidity and
mortality worldwide. Although the cancer survival rate has increased due to improved …