The UHRF protein family in epigenetics, development, and carcinogenesis

M Unoki, H Sasaki - Proceedings of the Japan Academy, Series B, 2022 - jstage.jst.go.jp
The UHRF protein family consists of multidomain regulatory proteins that sense modification
status of DNA and/or proteins and catalyze the ubiquitylation of target proteins. Through their …

A zebrafish HCT116 xenograft model to predict anandamide outcomes on colorectal cancer

F Maradonna, CM Fontana, F Sella, C Giommi… - Cell Death & …, 2022 - nature.com
Colon cancer is one of the leading causes of death worldwide. In recent years, cannabinoids
have been extensively studied for their potential anticancer effects and symptom …

Multifaceted behavior of PEST sequence enriched nuclear proteins in cancer biology and role in gene therapy

M Sarfraz, A Afzal, S Khattak… - Journal of Cellular …, 2021 - Wiley Online Library
The amino acid sequence enriched with proline (P), glutamic acid (E), serine (S), and
threonine (T)(PEST) is a signal‐transducing agent providing unique features to its substrate …

LINC00858 promotes colon cancer progression through activation of STAT3/5 signaling by recruiting transcription factor RAD21 to upregulate PCNP

T Xu, K Wu, J Shi, L Ji, X Song, G Tao, S Zheng… - Cell death …, 2022 - nature.com
The purpose of our investigation is to explore the putative molecular mechanisms
underpinning LINC00858 involvement in colon cancer. The expression of LINC00858 in …

[HTML][HTML] PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer

YG Chen, HX Liu, Y Hong, PZ Dong… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Thyroid cancer (TC) has increased globally, with a prominent increase in small, papillary
thyroid cancers. PEST-containing nuclear protein (PCNP), a nuclear protein, has been found …

[HTML][HTML] UHRF2 promotes hepatocellular carcinoma progression by upregulating ErbB3/Ras/Raf signaling pathway

J Sun, K Wu, S Chen, S Jiang, Y Chen… - International Journal of …, 2021 - ncbi.nlm.nih.gov
Emerging evidence revealed that UHRF2 was implicated in a variety of human diseases,
especially in cancer. However, the biological function, clinical significance and underly …

Tissue mechanics modulate PCNP expression in oral squamous cell carcinomas with different differentiation

L Zhang, D Guo, J Shen, Y Zheng, J Zhai, R Li… - Frontiers in …, 2023 - frontiersin.org
Background PEST-containing nuclear protein (PCNP), a novel zinc finger protein,
participates in cell cycle regulation. Previous studies have confirmed that PCNP plays a role …

Biology of PEST‐Containing Nuclear Protein: A Potential Molecular Target for Cancer Research

NH Khan, HJ Chen, Y Fan, M Surfaraz… - Frontiers in …, 2022 - frontiersin.org
PEST-containing nuclear protein (PCNP), a novel nuclear protein, is involved in vital cellular
processes like cell proliferation and mediates tumorigenesis. PCNP is a short-living, small …

[PDF][PDF] Structural, functional, phylogenetic, and molecular dynamic simulation study of PEST-containing nuclear protein: An e-science view

NH Khan, M Shahid, W Wang, S Khatak… - Gene Protein …, 2022 - pcnp.henu.edu.cn
PEST-containing nuclear protein (PCNP) is a short-lived novel nuclear protein. It has been
well evaluated that PCNP mediates the progression of several cancers, but the exact …

Characterization of self-regulatory mechanisms and internal dynamics of ETS transcription factor PU. 1

S Esaki - 2020 - scholarworks.gsu.edu
The ETS family of transcription factors bind to site-specific DNA via DNA-binding domains
called the ETS domains. The ETS domains are structurally homologous but divergent in …