The neural basis of psychedelic action
Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …
perception, cognition and mood. In this review, we focus on the basic neurobiology …
Ligands of adrenergic receptors: a structural point of view
Y Wu, L Zeng, S Zhao - Biomolecules, 2021 - mdpi.com
Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine.
They are targets of many drugs for various conditions, including treatment of hypertension …
They are targets of many drugs for various conditions, including treatment of hypertension …
Molecular recognition of morphine and fentanyl by the human μ-opioid receptor
Morphine and fentanyl are among the most used opioid drugs that confer analgesia and
unwanted side effects through both G protein and arrestin signaling pathways of μ-opioid …
unwanted side effects through both G protein and arrestin signaling pathways of μ-opioid …
Structure-based discovery of nonhallucinogenic psychedelic analogs
D Cao, J Yu, H Wang, Z Luo, X Liu, L He, J Qi, L Fan… - Science, 2022 - science.org
Drugs that target the human serotonin 2A receptor (5-HT2AR) are used to treat
neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use …
neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use …
Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo
Dopamine (DA) plays multiple roles in a wide range of physiological and pathological
processes via a large network of dopaminergic projections. To dissect the spatiotemporal …
processes via a large network of dopaminergic projections. To dissect the spatiotemporal …
GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
Summary Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that
activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of G …
activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of G …
Recognition of methamphetamine and other amines by trace amine receptor TAAR1
Trace amine-associated receptor 1 (TAAR1), the founding member of a nine-member family
of trace amine receptors, is responsible for recognizing a range of biogenic amines in the …
of trace amine receptors, is responsible for recognizing a range of biogenic amines in the …
Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes
Dopamine receptors, including D1-and D2-like receptors, are important therapeutic targets
in a variety of neurological syndromes, as well as cardiovascular and kidney diseases. Here …
in a variety of neurological syndromes, as well as cardiovascular and kidney diseases. Here …
Dynamic spatiotemporal determinants modulate GPCR: G protein coupling selectivity and promiscuity
Recent studies have shown that G protein coupled receptors (GPCRs) show selective and
promiscuous coupling to different Gα protein subfamilies and yet the mechanisms of the …
promiscuous coupling to different Gα protein subfamilies and yet the mechanisms of the …
Structural basis of the ligand binding and signaling mechanism of melatonin receptors
Q Wang, Q Lu, Q Guo, M Teng, Q Gong, X Li… - Nature …, 2022 - nature.com
Melatonin receptors (MT1 and MT2 in humans) are family AG protein–coupled receptors that
respond to the neurohormone melatonin to regulate circadian rhythm and sleep. Numerous …
respond to the neurohormone melatonin to regulate circadian rhythm and sleep. Numerous …