Alternative splicing of pre-mRNA increases genetic diversity, and recent studies estimate
that most human multiexon genes are alternatively spliced. If this process is not highly …

Examples of associations between human disease and defects in pre–messenger RNA
splicing/alternative splicing are accumulating. Although many alterations are caused by …

SR and hnRNP proteins were initially discovered as regulators of alternative splicing: the
process of controlled removal of introns and selective joining of exons through which …

Background Intensive evidence has highlighted the effect of aberrant alternative splicing
(AS) events on cancer progression when triggered by dysregulation of the SR protein family …

The number of factors known to participate in the DNA damage response (DDR) has
expanded considerably in recent years to include splicing and alternative splicing factors …

Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a
given gene, which can have distinct functions. In fact, splice isoforms can have opposing …

Pre-mRNA splicing is a fundamental process that plays a considerable role in generating
protein diversity. Pre-mRNA splicing is also the key to the pathology of numerous diseases …

Pulmonary fibrosis (PF) is a type of interstitial pneumonia with complex etiology and high
mortality, characterized by progressive scarring of the alveolar interstitium and …

Background Glioblastoma is one of the most devastating cancer worldwide based on its
locally aggressive behavior and because it cannot be cured by current therapies. Defects in …

MYC is a transcription factor, which not only directly modulates multiple aspects of
transcription and co‐transcriptional processing (eg RNA‐Polymerase II initiation, elongation …