MeCP2 ubiquitination and sumoylation, in search of a function

L Kalani, BH Kim, JB Vincent… - Human Molecular …, 2024 - academic.oup.com
Abstract MeCP2 (Methyl CpG binding protein 2) is an intrinsically disordered protein that
binds to methylated genome regions. The protein is a critical transcriptional regulator of the …

Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer's Disease: A Recent Systematic Review

C Munteanu, DA Iordan, M Hoteteu, C Popescu… - International Journal of …, 2023 - mdpi.com
In the rapidly evolving field of Alzheimer's Disease (AD) research, the intricate role of
Hydrogen Sulfide (H2S) has garnered critical attention for its diverse involvement in both …

Endothelial SHANK3 regulates tight junctions in the neonatal mouse blood-brain barrier through β-Catenin signaling

YE Kim, M Kim, S Kim, R Lee, Y Ujihara… - Nature …, 2025 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disability condition arising from a
combination of genetic and environmental factors. Despite the blood-brain barrier (BBB) …

Metabolic characterization of neurogenetic disorders involving glutamatergic neurotransmission

S Illescas, Y Diaz‐Osorio, A Serradell… - Journal of Inherited …, 2024 - Wiley Online Library
The study of inborn errors of neurotransmission has been mostly focused on monoamine
disorders, GABAergic and glycinergic defects. The study of the glutamatergic synapse using …

Mecp2 knock-out astrocytes affect synaptogenesis by interleukin 6 dependent mechanisms

E Albizzati, M Breccia, E Florio, C Cabasino… - Iscience, 2024 - cell.com
Synaptic abnormalities are a hallmark of several neurological diseases, and clarification of
the underlying mechanisms represents a crucial step toward the development of therapeutic …

[HTML][HTML] miR126-mediated impaired vascular integrity in Rett syndrome

T Osaki, Z Wan, K Haratani, Y Jin, M Campisi… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rett syndrome (RTT) is a neurodevelopmental disorder that is caused by mutations in melty-
CpG binding protein 2 (MeCP2). MeCP2 is a non-cell type-specific DNA binding protein, and …

Otizm Spektrum Bozukluğunda Mikroglia ve Astrositler Tarafından Aracılık Edilen Nöroinflamasyon ve Sinaptik Hassasiyet

DA Yılmaz, İH Çağıran - Nuh'un Gemisi Sağlık Bilimleri Dergisi, 2024 - dergipark.org.tr
Otizm spektrum bozukluğu (OSB), çocukluk döneminde başlayan ve yaygın bir
nörogelişimsel bozukluk olarak kabul edilmektedir. OSB'nin patofizyolojik temelleri henüz …

Endothelial SHANK3 Controls Tight Junction of Neonatal Blood-Brain Barrier

IH Kim, YE Kim, M Kim, S Kim, R Lee, Y Ujihara… - 2024 - researchsquare.com
Autism spectrum disorder (ASD) is a neurodevelopmental disability condition arising from
the combination of genetic and environmental factors. Despite the blood-brain barrier (BBB) …