Photodynamic therapy (PDT) is a clinical modality used to treat cancer and infectious
diseases. The main agent is the photosensitizer (PS), which is excited by light and converted …

Lipid oxidation encompasses chemical transformations affecting animals and plants in many
ways, and light is one of the most common triggers of lipid oxidation in our habitat. Still, the …

Although the general mechanisms of lipid oxidation are known, the chemical steps through
which photosensitizers and light permeabilize lipid membranes are still poorly understood …

The cell membrane forms a dynamic and complex barrier between the living cell and its
environment. However, its in vivo studies are difficult because it consists of a high variety of …

It is well-known that aqueous dispersions of phospholipids spontaneously assemble into
bilayer structures. These structures have numerous applications across chemistry and …

Closed lipid bilayers in the form of giant unilamellar vesicles (GUVs) are commonly used
membrane models. Various methods have been developed to prepare GUVs, however it is …

Cell delivery or cell killing processes often involve the crossing or disruption of cellular
membranes. We review how, by modifying the composition and properties of membranes …

Oxidation of unsaturated lipids in cellular membranes has been shown to cause severe
membrane damage and potentially cell death. The presence of oxidized lipid species in the …

Electroporation or electropermeabilization is a technique that enables transient increase in
the cell membrane permeability by exposing cells to pulsed electric field. However, the …

The influence of different oxidized lipids on lipid bilayers was investigated with 16 individual
1 μs atomistic molecular dynamics (MD) simulations. Binary mixtures of lipid bilayers of 1 …