[HTML][HTML] Inborn errors of human B cell development, differentiation, and function
B cells develop from hematopoietic stem cells in the bone marrow. Once generated, they
serve multiple roles in immune regulation and host defense. However, their most important …
serve multiple roles in immune regulation and host defense. However, their most important …
The role of the CBM complex in allergic inflammation and disease
SB DeVore, GKK Hershey - Journal of Allergy and Clinical Immunology, 2022 - Elsevier
The caspase activation and recruitment domain-coiled-coil (CARD-CC) family of proteins—
CARD9, CARD10, CARD11, and CARD14—is collectively expressed across nearly all …
CARD9, CARD10, CARD11, and CARD14—is collectively expressed across nearly all …
Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1
AN Jones, C Graß, I Meininger, A Geerlof… - Science …, 2022 - science.org
Alternative splicing plays key roles for cell type–specific regulation of protein function. It is
controlled by cis-regulatory RNA elements that are recognized by RNA binding proteins …
controlled by cis-regulatory RNA elements that are recognized by RNA binding proteins …
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease
TJ O'Neill, T Seeholzer, A Gewies, T Gehring… - Science …, 2021 - science.org
Balanced control of T cell signaling is critical for adaptive immunity and protection from
autoimmunity. By combining genetically engineered mouse models, biochemical analyses …
autoimmunity. By combining genetically engineered mouse models, biochemical analyses …
Expanding the clinical and immunological phenotypes and natural history of MALT1 deficiency
AP Sefer, H Abolhassani, F Ober, B Kayaoglu… - Journal of clinical …, 2022 - Springer
Purpose MALT1 deficiency is a combined immune deficiency characterized by recurrent
infections, eczema, chronic diarrhea, and failure to thrive. Clinical and immunological …
infections, eczema, chronic diarrhea, and failure to thrive. Clinical and immunological …
Human lncRNA SUGCT-AS1 Regulates the Proinflammatory Response of Macrophage
YH Lim, G Yoon, Y Ryu, D Jeong, J Song… - International Journal of …, 2023 - mdpi.com
Macrophages are the major primary immune cells that mediate the inflammatory response.
In this process, long non-coding RNAs (lncRNAs) play an important, yet largely unknown …
In this process, long non-coding RNAs (lncRNAs) play an important, yet largely unknown …
Monogenic etiologies of persistent human papillomavirus infections: A comprehensive systematic review
S Biglari, AS Moghaddam, MA Tabatabaiefar… - Genetics in …, 2024 - Elsevier
Purpose Persistent human papillomavirus infection (PHPVI) causes cutaneous, anogenital,
and mucosal warts. Cutaneous warts include common warts, Treeman syndrome, and …
and mucosal warts. Cutaneous warts include common warts, Treeman syndrome, and …
Human MALT1 deficiency and predisposition to infections
Highlights•Pulmonary, skin, gastrointestinal, and blood infections were the most
common.•70% of patients experienced S. aureus, C. albicans, and cytomegalovirus …
common.•70% of patients experienced S. aureus, C. albicans, and cytomegalovirus …
MALT1 substrate cleavage: what is it good for?
BN Moud, F Ober, TJ O'Neill, D Krappmann - Frontiers in Immunology, 2024 - frontiersin.org
CARD-BCL10-MALT1 (CBM) signalosomes connect distal signaling of innate and adaptive
immune receptors to proximal signaling pathways and immune activation. Four CARD …
immune receptors to proximal signaling pathways and immune activation. Four CARD …
Current genetic defects in common variable immunodeficiency patients on the geography between Europe and Asia: a single-center experience
Identification of the causes of monogenetic common variable immunodeficiency (CVID)
patients has rapidly increased in the last years by means of worldwide availability of …
patients has rapidly increased in the last years by means of worldwide availability of …