Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control
methods that bias the sex ratio of insect offspring have long been sought. Genetic elements …

CRISPR-based gene-drives targeting the gene doublesex in the malaria vector Anopheles
gambiae effectively suppressed the reproductive capability of mosquito populations reared …

It has been theorized that inducing extreme reproductive sex ratios could be a method to
suppress or eliminate pest populations. Limited knowledge about the genetic makeup and …

Mosquito-borne diseases such as malaria, dengue, Zika, and chikungunya cause significant
morbidity and mortality globally, resulting in over 600,000 deaths from malaria and around …

Background The symbiotic bacterium Wolbachia is currently being trialled as a biocontrol
agent in several countries to reduce dengue transmission. Wolbachia can invade and …

CRISPR-based gene drives have the potential to spread within populations and are
considered as promising vector control tools. A doublesex-targeting gene drive was able to …

Gene drives for mosquito population modification are novel tools for malaria control.
Strategies to safely test antimalarial effectors in the field are required. Here, we modified the …

Background Mosquito-borne diseases exert a huge impact on both animal and human
populations, posing substantial health risks. The behavioural and fitness traits of …

The continuous expansion of exotic Aedine mosquito species potential vectors of pathogens
into new areas is a public health concern. In continental Europe, the surveillance of these …

Pyrethroid resistance in malaria vectors has spread across sub-Saharan Africa. Alternative
tools and molecules are urgently needed for effective vector control. One of the most …