TO Nielsen, SCY Leung, DL Rimm… - JNCI: Journal of the …, 2021 - academic.oup.com
Abstract Ki67 immunohistochemistry (IHC), commonly used as a proliferation marker in breast cancer, has limited value for treatment decisions due to questionable analytical …
TJ Whelan, S Smith, S Parpia, AW Fyles… - … England Journal of …, 2023 - Mass Medical Soc
Background Adjuvant radiotherapy is prescribed after breast-conserving surgery to reduce the risk of local recurrence. However, radiotherapy is inconvenient, costly, and associated …
F Cardoso, S Kyriakides, S Ohno… - Annals of …, 2019 - annalsofoncology.org
In 2018, the predicted number of new breast cancers in 28 European Union (EU) countries was 404 920, with estimated age-adjusted annual incidence of breast cancer of 144.9/100 …
Pathology is the cornerstone of cancer care. The need for accuracy in histopathologic diagnosis of cancer is increasing as personalized cancer therapy requires accurate …
Ki-67 protein has been widely used as a proliferation marker for human tumor cells for decades. In recent studies, multiple molecular functions of this large protein have become …
E Senkus, S Kyriakides, S Ohno… - Annals of …, 2015 - annalsofoncology.org
In 2012, the estimated age-adjusted annual incidence of breast cancer in 40 European countries was 94.2/100 000 and the mortality 23.1/100 000 [1]. The incidence increased …
LN Harris, N Ismaila, LM McShane… - Journal of oncology …, 2016 - ascopubs.org
Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: American So Page 1 Case Western Reserve University, Cleveland, OH; …
MJ Duffy, N Harbeck, M Nap, R Molina… - European journal of …, 2017 - Elsevier
Biomarkers play an essential role in the management of patients with invasive breast cancer. For selecting patients likely to respond to endocrine therapy, both oestrogen …
A Prat, E Pineda, B Adamo, P Galván, A Fernández… - The Breast, 2015 - Elsevier
Gene-expression profiling has had a considerable impact on our understanding of breast cancer biology. During the last 15 years, 5 intrinsic molecular subtypes of breast cancer …