The mechanisms underlying bone development, repair and regeneration are reliant on the
interplay and communication between osteoclasts and other surrounding cells. Osteoclasts …

Bone is one of the key components of the musculoskeletal system. Bone and joint disease
are the fourth most widespread disease, in addition to cardiovascular disease, cancer, and …

Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …

The ontogeny and fate of stem cells have been extensively investigated by lineage-tracing
approaches. At distinct anatomical sites, bone tissue harbors multiple types of skeletal stem …

Runx1 is highly expressed in osteoblasts, however, its function in osteogenesis is unclear.
We generated mesenchymal progenitor-specific (Runx1 f/f Twist2-Cre) and osteoblast …

The Ten-eleven translocation (TET) family of dioxygenases mediate cytosine demethylation
by catalyzing the oxidation of 5-methylcytosine (5mC). TET-mediated DNA demethylation …

Bone regeneration originates from proliferation and differentiation of osteoprogenitors via
either endochondral or intramembranous ossification; and the regeneration capacities …

Heterotopic ossification (HO) is pathological bone formation characterized by ossification
within muscle, tendons, or other soft tissues. However, the cells of origin and mechanisms …

Deficient bone regeneration causes bone defects or nonunion in a substantial proportion of
trauma patients that urges for novel therapies. To develop a reliable therapy, we …

Chromothripsis is a catastrophic event of chromosomal instability that involves intensive
fragmentation and rearrangements within localized chromosomal regions. However, its …