Dynamic responses of striatal cholinergic interneurons control behavioral flexibility

Z Huang, R Chen, M Ho, X Xie, H Gangal, X Wang… - Science …, 2024 - science.org
Striatal cholinergic interneurons (CINs) are key to regulating behavioral flexibility, involving
both extinguishing learned actions and adopting new ones. However, the mechanisms …

[HTML][HTML] What role does striatal dopamine play in goal-directed action?

G Hart, TJ Burton, BW Balleine - Neuroscience, 2024 - Elsevier
Evidence suggests that dopamine activity provides a US-related prediction error for
Pavlovian conditioning and the reinforcement signal supporting the acquisition of habits …

Inflammaging and immunosenescence in the post‐COVID era: small molecules, big challenges

F Francavilla, F Intranuovo, G La Spada… - …, 2024 - Wiley Online Library
Aging naturally involves a decline in biological functions, often triggering a disequilibrium of
physiological processes. A common outcome is the altered response exerted by the immune …

Ellagitannin Component Punicalin Ameliorates Cognitive Dysfunction, Oxidative Stress, and Neuroinflammation via the Inhibition of cGAS‐STING Signaling in the …

P Chen, Z Zhang, J Lei, J Zhu, G Liu - Phytotherapy Research, 2024 - Wiley Online Library
Despite remarkable breakthroughs in pharmacotherapy, many potential therapies for aging
remain unexplored. Punicalin (PUN), an ellagitannin component, exerts anti‐inflammatory …

Striatal Acetylcholine and Dopamine Interactions Produce Situationappropriate Action Selection

LA Bradfield, S Becchi… - Current …, 2024 - benthamdirect.com
Individuals often learn how to perform new actions for particular outcomes against a
complex background of existing action-outcome associations. As such, this new knowledge …

Distinct roles of two thalamostriatal systems in learning processes of visual discrimination in common marmosets

S Kato, M Sugawara, M Yamasaki, M Watanabe… - bioRxiv, 2024 - biorxiv.org
The thalamostriatal projections arising from the intralaminar thalamic nuclei (ILN) constitute
the principal source of input information to specified subregions of the striatum, a key …

Dynamic Responses of Striatal Cholinergic Interneurons Control the Extinction and Updating of Goal-Directed Learning

Z Huang, R Chen, M Ho, X Xie, X Wang, J Wang - bioRxiv, 2023 - biorxiv.org
Striatal cholinergic interneurons (CINs) regulate behavioral flexibility, but their exact
contribution to this process remains elusive. In this study, we report that extinction learning …

[PDF][PDF] Striatal Acetylcholine and Dopamine Interactions Produce Situation

LA Bradfield, S Becchi, MD Kendig - Neuron, 2013 - opus.lib.uts.edu.au
Individuals often learn how to perform new actions for particular outcomes against a
complex background of existing action-outcome associations. As such, this new knowledge …