Cellular functions of long noncoding RNAs
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …
are transcribed from the mammalian genome. They are emerging as important regulators in …
Long non-coding RNAs in the regulation of gene expression: physiology and disease
JCR Fernandes, SM Acuña, JI Aoki, LM Floeter-Winter… - Non-coding RNA, 2019 - mdpi.com
The identification of RNAs that are not translated into proteins was an important
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …
Towards a complete map of the human long non-coding RNA transcriptome
B Uszczynska-Ratajczak, J Lagarde… - Nature Reviews …, 2018 - nature.com
Gene maps, or annotations, enable us to navigate the functional landscape of our genome.
They are a resource upon which virtually all studies depend, from single-gene to genome …
They are a resource upon which virtually all studies depend, from single-gene to genome …
How do lncRNAs regulate transcription?
It has recently become apparent that RNA, itself the product of transcription, is a major
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …
Transcription regulation by long non-coding RNAs: mechanisms and disease relevance
J Ferrer, N Dimitrova - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …
New Insights into Long Non-Coding RNA MALAT1 in Cancer and Metastasis
Y Sun, L Ma - Cancers, 2019 - mdpi.com
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is one of the most
abundant, long non-coding RNAs (lncRNAs) in normal tissues. This lncRNA is highly …
abundant, long non-coding RNAs (lncRNAs) in normal tissues. This lncRNA is highly …
HOTAIR LncRNA: a novel oncogenic propellant in human cancer
T Rajagopal, S Talluri, RL Akshaya, NR Dunna - Clinica chimica acta, 2020 - Elsevier
Long non-coding RNAs (lncRNAs) are an important novel class of non-coding RNAs having
lengths of 200 nucleotides and low expression. The HOX Transcript Antisense Intergenic …
lengths of 200 nucleotides and low expression. The HOX Transcript Antisense Intergenic …
Mechanisms regulating PRC2 recruitment and enzymatic activity
D Holoch, R Margueron - Trends in biochemical sciences, 2017 - cell.com
Polycomb repressive complex 2 (PRC2) and its histone H3 lysine-27 methylation activity are
crucial for multicellular development by virtue of their role in maintaining transcriptional …
crucial for multicellular development by virtue of their role in maintaining transcriptional …
HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation
Y Li, W Sun, J Li, R Du, W Xing, X Yuan, G Zhong… - Bone Research, 2023 - nature.com
Bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoblast
function play critical roles in bone formation, which is a highly regulated process. Long …
function play critical roles in bone formation, which is a highly regulated process. Long …
Functional interaction among lncRNA HOTAIR and microRNAs in cancer and other human diseases
M Cantile, M Di Bonito, M Tracey De Bellis, G Botti - Cancers, 2021 - mdpi.com
Simple Summary This review aimed to describe the contribution of functional interaction
between the lncRNA HOTAIR and microRNAs in human diseases, including cancer …
between the lncRNA HOTAIR and microRNAs in human diseases, including cancer …