The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology

A Rutsch, JB Kantsjö, F Ronchi - Frontiers in immunology, 2020 - frontiersin.org
The human microbiota has a fundamental role in host physiology and pathology. Gut
microbial alteration, also known as dysbiosis, is a condition associated not only with …

Gut microbiome, liver immunology, and liver diseases

R Wang, R Tang, B Li, X Ma, B Schnabl… - Cellular & molecular …, 2021 - nature.com
The gut microbiota is a complex and plastic consortium of microorganisms that are intricately
connected with human physiology. The liver is a central immunological organ that is …

Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer

JX Han, ZH Tao, JL Wang, L Zhang, CY Yu… - Nature …, 2023 - nature.com
Epidemiological studies have indicated an association between statin use and reduced
incidence of colorectal cancer (CRC), and work in preclinical models has demonstrated a …

ALS genetics: gains, losses, and implications for future therapies

G Kim, O Gautier, E Tassoni-Tsuchida, XR Ma… - Neuron, 2020 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …

The contribution of the peripheral immune system to neurodegeneration

F Berriat, CS Lobsiger, S Boillée - Nature Neuroscience, 2023 - nature.com
Microglial cells are the major immune cells of the central nervous system (CNS), and directly
react to neurodegeneration, but other immune cell types are also able to react to pathology …

The microbiome as a modifier of neurodegenerative disease risk

P Fang, SA Kazmi, KG Jameson, EY Hsiao - Cell host & microbe, 2020 - cell.com
The gut microbiome is increasingly implicated in modifying susceptibility to and progression
of neurodegenerative diseases (NDs). In this review, we discuss roles for the microbiome in …

Genetics of amyotrophic lateral sclerosis: seeking therapeutic targets in the era of gene therapy

N Suzuki, A Nishiyama, H Warita, M Aoki - Journal of human genetics, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is an intractable disease that causes respiratory failure
leading to mortality. The main locus of ALS is motor neurons. The success of antisense …

ggpicrust2: an R package for PICRUSt2 predicted functional profile analysis and visualization

C Yang, J Mai, X Cao, A Burberry, F Cominelli… - …, 2023 - academic.oup.com
Microbiome research is now moving beyond the compositional analysis of microbial taxa in
a sample. Increasing evidence from large human microbiome studies suggests that …

The gut microbiota–brain axis in neurological disorder

H Ullah, S Arbab, Y Tian, C Liu, Y Chen… - Frontiers in …, 2023 - frontiersin.org
The gut microbiota (GM) plays an important role in the physiology and pathology of the host.
Microbiota communicate with different organs of the organism by synthesizing hormones …

[HTML][HTML] Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis

J Root, P Merino, A Nuckols, M Johnson… - Neurobiology of disease, 2021 - Elsevier
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal
neurodegenerative disorders that are thought to exist on a clinical and pathological …