Metabolism research has made tremendous progress over the last several decades in
establishing the adipocyte as a central rheostat in the regulation of systemic nutrient and …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Hormone-secreting cells within pancreatic islets of Langerhans play important roles in
metabolic homeostasis and disease. However, their transcriptional characterization is still …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Leptin is hypothesized to function as a negative feedback signal in the regulation of energy
balance. It is produced primarily by adipose tissue and circulating concentrations correlate …

Background The hormone leptin is an important regulator of metabolic homeostasis, able to
inhibit food intake and increase energy expenditure. Leptin can also independently lower …

The discovery of adipokines has revealed adipose tissue as a central node in the interorgan
crosstalk network, which mediates the regulation of multiple organs and tissues. Adipose …

Background Bisphenol A (BPA) is a widespread endocrine-disrupting chemical used as the
base compound in the manufacture of polycarbonate plastics. In humans, epidemiological …

In nonobese diabetic mice with uncontrolled type 1 diabetes, leptin therapy alone or
combined with low-dose insulin reverses the catabolic state through suppression of …

The fat‐derived hormone, leptin, is well known to regulate body weight. However, there is
now substantial evidence that leptin also plays a primary role in the regulation of glucose …