The past, present and future of anti-malarial medicines
Great progress has been made in recent years to reduce the high level of suffering caused
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …
by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria …
Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
Feeling nature's PAINS: natural products, natural product drugs, and pan assay interference compounds (PAINS)
JB Baell - Journal of natural products, 2016 - ACS Publications
We have previously reported on classes of compounds that can interfere with bioassays via
a number of different mechanisms and termed such compounds Pan Assay INterference …
a number of different mechanisms and termed such compounds Pan Assay INterference …
Natural product and natural product derived drugs in clinical trials
Covering: 2008–2013. Previous review: 2008, 25, 475 There are a significant number of
natural product (NP) drugs in development. We review the 100 NP and NP-derived …
natural product (NP) drugs in development. We review the 100 NP and NP-derived …
The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology
DB Graves - Journal of Physics D: Applied Physics, 2012 - iopscience.iop.org
Reactive oxygen species (ROS) and the closely related reactive nitrogen species (RNS) are
often generated in applications of atmospheric pressure plasmas intended for biomedical …
often generated in applications of atmospheric pressure plasmas intended for biomedical …
Artemisinin action and resistance in Plasmodium falciparum
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …
A novel multiple-stage antimalarial agent that inhibits protein synthesis
B Baragaña, I Hallyburton, MCS Lee, NR Norcross… - Nature, 2015 - nature.com
There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and
novel modes of action, to widen the scope of treatment and to overcome emerging drug …
novel modes of action, to widen the scope of treatment and to overcome emerging drug …
The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives
L Wanka, K Iqbal, PR Schreiner - Chemical reviews, 2013 - ACS Publications
A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …
Malaria biology and disease pathogenesis: insights for new treatments
LH Miller, HC Ackerman, X Su, TE Wellems - Nature medicine, 2013 - nature.com
Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan,
claims the lives of nearly a million children each year in Africa alone and is a top public …
claims the lives of nearly a million children each year in Africa alone and is a top public …