The fragmentation pathways of protonated peptides are reviewed in the present paper
paying special attention to classification of the known fragmentation channels into a simple …

Protein identification and peptide sequencing by tandem mass spectrometry requires
knowledge of how peptides fragment in the gas phase, specifically which bonds are broken …

The most commonly used activation method in the tandem mass spectrometry (MS) of
peptides and proteins is energetic collisions with a neutral target gas. The overall process of …

The use of mass spectrometry in macromolecular analysis is an incredibly important
technique and has allowed efficient identification of secondary and tertiary protein …

Abstract I. Introduction 58 A. Challenges in the Gas‐Phase Fragmentation of Polypeptides
58 B. Ion–Electron Interactions 58 C. Nomenclature 59 II. Instrumental Realization and …

We performed a large scale study of electron transfer dissociation (ETD) performance, as
compared with ion trap collision-activated dissociation (CAD), for peptides ranging from∼ …

Electron-transfer dissociation (ETD) delivers the unique attributes of electron capture
dissociation to mass spectrometers that utilize radio frequency trapping-type devices (eg …

This review presents a brief historical introduction to the development of tandem mass
spectrometry and its principal applications. It is placed in the context of the general …

Integral membrane proteins (IMPs) lie at the critical junctions between intracellular
compartments and cells and their environment. As such, IMPs are in a unique position to …

Pioneering work by, among others, the groups of Hunt and Mann at the start of this century
opened up the era of mass spectrometry (MS)-based phosphoproteomics. 1− 3 Through …