Abstract tRNAs are key partners in ribosome-dependent protein synthesis. This process is
highly dependent on the fidelity of tRNA aminoacylation by aminoacyl-tRNA synthetases …

Ribosome-dependent protein biosynthesis is an essential cellular process mediated by
transfer RNAs (tRNAs). Generally, ribosomally synthesized proteins are limited to the 22 …

Transfer RNAs (tRNAs) in bacteriophage genomes are widespread across bacterial host
genera, but their exact function has remained unclear for more than 50 years. Several …

As the most abundant biological entities on the planet, viruses significantly influence the
overall functioning of marine ecosystems. The abundance, distribution, and biodiversity of …

Metazoan organisms have many tRNA genes responsible for decoding amino acids. The set
of all tRNA genes can be grouped in sets of common amino acids and isoacceptor tRNAs …

Inaccurate expression of the genetic code, also known as mistranslation, is an emerging
paradigm in microbial studies. Growing evidence suggests that many microbial pathogens …

As a class of essential enzymes in protein translation, aminoacyl–transfer RNA (tRNA)
synthetases (aaRSs) are organized into two classes of 10 enzymes each, based on two …

T-box riboswitches constitute a large family of tRNA-binding leader sequences that play a
central role in gene regulation in many gram-positive bacteria. Accurate inference of the …

The rules of the genetic code are implemented by the unique features that define the amino
acid identity of each transfer RNA (tRNA). These features, known as “identity elements,” …

Accurate translation of genetic information into proteins is vital for cell sustainability. ProXp-
ala prevents proteome-wide Pro-to-Ala mutations by hydrolyzing misacylated Ala-tRNA Pro …