Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents

MF Arshad, A Alam, AA Alshammari, MB Alhazza… - Molecules, 2022 - mdpi.com
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …

Hybrid molecules based on 1, 3, 5‐triazine as potential therapeutics: A focused review

P Prasher, M Sharma, AAA Aljabali… - Drug development …, 2020 - Wiley Online Library
Majority of the representative drugs customarily interact with multiple targets manifesting
unintended side effects. In addition, drug resistance and over expression of the cellular …

Synthesis, spectroscopic characterization, antimicrobial evaluation and molecular docking study of novel triazine-quinazolinone based hybrids

M Dinari, F Gharahi, P Asadi - Journal of Molecular Structure, 2018 - Elsevier
Abstract A new series of 1, 3, 5-triazine incorporating aromatic quinazolinone moieties as a
potential antimicrobial agents is reported. The first chlorine group of the cyanuric chloride (1) …

Molecular modeling and biological investigation of novel s-triazine linked benzothiazole and coumarin hybrids as antimicrobial and antimycobacterial agents

AR Zala, D Kumar, U Razakhan, DP Rajani… - Journal of …, 2024 - Taylor & Francis
A novel series of s-triazine linked benzothiazole and coumarin hybrids (6a-6d, 7a-7d, and
8a-8d) were synthesized and characterized by IR, NMR, and mass spectrometry. The …

Heterocyclic compounds bearing triazine scaffold and their biological significance: A review

T Verma, M Sinha, N Bansal - Anti-Cancer Agents in Medicinal …, 2020 - ingentaconnect.com
Benzene is a six-membered hydrocarbon ring system and if three carbon-hydrogen units of
benzene ring are replaced by nitrogen atoms then triazine is formed. Triazines are present …

Design, Synthesis, Molecular Docking, Drug-Likeness/ADMET and Molecular Dynamics Studies of Thiazolyl Benzenesulfonamide Carboxylates as Antimalarial …

JA Ezugwu, UC Okoro, MA Ezeokonkwo… - Chemistry Africa, 2024 - Springer
In this work, nine novel thiazole derivatives of substituted benzenesulfonamide carboxylate
were designed, synthesized and characterized (1H NMR, 13C NMR and Mass Spectra) for …

A Review on Synthetic Thiazole Derivatives as an Antimalarial Agent

T Kalita, A Choudhury, A Shakya… - Current Drug …, 2024 - benthamdirect.com
Background: Thiazole is a widely studied core structure in heterocyclic chemistry and has
proven to be a valuable scaffold in medicinal chemistry. The presence of thiazole in both …

Microwave-accelerated carbon-carbon and carbon-heteroatom bond formation via multi-component reactions: a brief overview

K Kamanna, SY Khatavi - Current Microwave Chemistry, 2020 - ingentaconnect.com
Multi-Component Reactions (MCRs) have emerged as an excellent tool in organic chemistry
for the synthesis of various bioactive molecules. Among these, one-pot MCRs are included …

The Riveting Chemistry of Poly‐aza‐heterocycles Employing Microwave Technique: A Decade Review

JP Soni, SV Joshi, KS Chemitikanti… - European Journal of …, 2021 - Wiley Online Library
The application of microwave technique in chemical laboratory rooted back in 1986 and
found advantageous over conventional approaches. On the other side, poly‐aza …

Discovery of potential 1, 3, 5-Triazine compounds against strains of Plasmodium falciparum using supervised machine learning models

S Sahu, SK Ghosh, JM Kalita, MC Ginjupalli - European Journal of …, 2020 - Elsevier
The Malaria burden was an escalating global encumbrance and need to be addressed with
critical care. Anti-malarial drug discovery was integrated with supervised machine learning …