Neutrophils at work

WM Nauseef, N Borregaard - Nature immunology, 2014 - nature.com
In this Review we discuss data demonstrating recently recognized aspects of neutrophil
homeostasis in the steady state, granulopoiesis in'emergency'conditions and interactions of …

[HTML][HTML] The role of NADPH oxidases in infectious and inflammatory diseases

JP Taylor, MT Hubert - Redox biology, 2021 - Elsevier
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) are enzymes that
generate superoxide or hydrogen peroxide from molecular oxygen utilizing NADPH as an …

[HTML][HTML] Pharmacological characterization of the seven human NOX isoforms and their inhibitors

F Augsburger, A Filippova, D Rasti, T Seredenina… - Redox biology, 2019 - Elsevier
Background NADPH oxidases (NOX) are a family of flavoenzymes that catalyze the
formation of superoxide anion radical (O 2•-) and/or hydrogen peroxide (H 2 O 2). As major …

Redox reactions and microbial killing in the neutrophil phagosome

CC Winterbourn, AJ Kettle - Antioxidants & redox signaling, 2013 - liebertpub.com
Significance: When neutrophils kill microorganisms, they ingest them into phagosomes and
bombard them with a burst of reactive oxygen species. Recent Advances: This review …

The Concise Guide to PHARMACOLOGY 2013/14: ion channels

SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Voltage-Gated Proton Channels: Molecular Biology, Physiology, and Pathophysiology of the HV Family

TE DeCoursey - Physiological reviews, 2013 - journals.physiology.org
Voltage-gated proton channels (HV) are unique, in part because the ion they conduct is
unique. HV channels are perfectly selective for protons and have a very small unitary …

Regulation of the NADPH oxidase and associated ion fluxes during phagocytosis

P Nunes, N Demaurex, MC Dinauer - Traffic, 2013 - Wiley Online Library
The production of reactive oxygen species (ROS) within immune cell phagosomes is critical
for antimicrobial activity and for correct antigen processing, and influences signaling …

The formation and function of the neutrophil phagosome

E Naish, AJT Wood, AP Stewart… - Immunological …, 2023 - Wiley Online Library
Neutrophils are the most abundant circulating leukocyte and are crucial to the initial innate
immune response to infection. One of their key pathogen‐eliminating mechanisms is …

NOX5 in human spermatozoa: expression, function, and regulation

B Musset, RA Clark, TE DeCoursey, GL Petheo… - Journal of Biological …, 2012 - ASBMB
Physiological and pathological processes in spermatozoa involve the production of reactive
oxygen species (ROS), but the identity of the ROS-producing enzyme system (s) remains a …

Voltage-gated proton channel in a dinoflagellate

SME Smith, D Morgan, B Musset… - Proceedings of the …, 2011 - National Acad Sciences
Fogel and Hastings first hypothesized the existence of voltage-gated proton channels in
1972 in bioluminescent dinoflagellates, where they were thought to trigger the flash by …