Sphingolipid metabolism in metazoan cells consists of a complex interconnected web of
numerous enzymes, metabolites and modes of regulation. At the centre of sphingolipid …

In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important
signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of …

The traditional view is that cancer cells predominately produce ATP by glycolysis, rather
than by oxidation of energy-providing substrates. Mitochondrial uncoupling—the continuing …

Ceramides, composed of a sphingosine and a fatty acid, are bioactive lipid molecules
involved in many key cellular pathways (eg, apoptosis, oxidative stress and inflammation) …

Different studies corroborate a role for ceramide synthases and their downstream products,
ceramides, in modulation of apoptosis and autophagy in the context of cancer. These …

Ceramide, the precursor of all complex sphingolipids, is a potent signaling molecule that
mediates key events of cellular pathophysiology. In the nervous system, the sphingolipid …

Acid sphingomyelinase occupies a prominent position in sphingolipid catabolism, catalyzing
the hydrolysis of sphingomyelin to ceramide and phosphorylcholine. Enzymatic dysfunction …

Sphingolipids (SFs) represent a large class of lipids playing diverse functions in a vast
number of physiological and pathological processes. Sphingomyelin (SM) is the most …

Programmed cell death, or apoptosis, is a complex process whereby eukaryotic cells react to
physiologic or pathophysiologic stimuli by undergoing genetically programmed suicide …

We have generated a mouse that cannot synthesize very long acyl chain (C22–C24)
ceramides (Pewzner-Jung, Y., Park, H., Laviad, EL, Silva, LC, Lahiri, S., Stiban, J., Erez …